Effects of indoor particulate matter exposure on daily asthma control.
Air Pollution, Indoor
/ adverse effects
Allergens
/ immunology
Animals
Antigens, Dermatophagoides
/ immunology
Arthropod Proteins
/ immunology
Asthma
/ drug therapy
Cysteine Endopeptidases
/ immunology
Dust
/ immunology
Environmental Exposure
Female
Humans
Immunoglobulin E
/ blood
Male
Middle Aged
Particulate Matter
/ adverse effects
Prospective Studies
Pyroglyphidae
/ immunology
Quality of Life
Surveys and Questionnaires
Journal
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
ISSN: 1534-4436
Titre abrégé: Ann Allergy Asthma Immunol
Pays: United States
ID NLM: 9503580
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
06
03
2019
revised:
17
07
2019
accepted:
20
07
2019
pubmed:
29
7
2019
medline:
11
3
2020
entrez:
29
7
2019
Statut:
ppublish
Résumé
Household dust often contains aeroallergens, such as the house dust mite antigen Der p 1. It has been proposed that overnight exposure to particulate matter from bedding and other sources may be an important driver of atopic asthma. Whether variability in overnight particulate matter exposure is a significant determinant of asthma control is unknown. To test the hypothesis that overnight particulate matter exposure is associated with day-to-day symptoms, lung function, and airway inflammation in patients with asthma who are sensitized to house dust mite. We undertook a prospective, single-center panel study in 28 adults with asthma and house dust mite sensitization. Overnight exposure to particulate matter was measured using a commercially available indoor air quality monitor. Symptom scores, peak expiratory flow, and exhaled nitric oxide were measured and electronically recorded daily. Participants were followed up for 12 weeks and attended study visits every 4 weeks, at which they underwent spirometry and completed the Asthma Control Questionnaire and Asthma Quality of Life Questionnaire. Data were analyzed using cross-correlation and linear mixed-effects models. No significant associations were observed between overnight particulate matter exposure and clinical outcomes measured daily or at study visits. Natural variability in overnight particulate matter exposure does not appear to be a major determinant of daily asthma control in patients with asthma and house dust mite sensitization.
Sections du résumé
BACKGROUND
Household dust often contains aeroallergens, such as the house dust mite antigen Der p 1. It has been proposed that overnight exposure to particulate matter from bedding and other sources may be an important driver of atopic asthma. Whether variability in overnight particulate matter exposure is a significant determinant of asthma control is unknown.
OBJECTIVE
To test the hypothesis that overnight particulate matter exposure is associated with day-to-day symptoms, lung function, and airway inflammation in patients with asthma who are sensitized to house dust mite.
METHODS
We undertook a prospective, single-center panel study in 28 adults with asthma and house dust mite sensitization. Overnight exposure to particulate matter was measured using a commercially available indoor air quality monitor. Symptom scores, peak expiratory flow, and exhaled nitric oxide were measured and electronically recorded daily. Participants were followed up for 12 weeks and attended study visits every 4 weeks, at which they underwent spirometry and completed the Asthma Control Questionnaire and Asthma Quality of Life Questionnaire. Data were analyzed using cross-correlation and linear mixed-effects models.
RESULTS
No significant associations were observed between overnight particulate matter exposure and clinical outcomes measured daily or at study visits.
CONCLUSION
Natural variability in overnight particulate matter exposure does not appear to be a major determinant of daily asthma control in patients with asthma and house dust mite sensitization.
Identifiants
pubmed: 31351980
pii: S1081-1206(19)30538-1
doi: 10.1016/j.anai.2019.07.020
pii:
doi:
Substances chimiques
Allergens
0
Antigens, Dermatophagoides
0
Arthropod Proteins
0
Dust
0
Particulate Matter
0
Immunoglobulin E
37341-29-0
Cysteine Endopeptidases
EC 3.4.22.-
Dermatophagoides pteronyssinus antigen p 1
EC 3.4.22.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
375-380.e3Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
Pays : United Kingdom
Organisme : British Heart Foundation
Pays : United Kingdom
Organisme : Arthritis Research UK
Pays : International
Informations de copyright
Copyright © 2019 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.