Restoration of Cdk5, TrkB and Soluble N-ethylmaleimide-Sensitive Factor Attachment Protein Receptor Proteins after Chronic Methylphenidate Treatment in Spontaneous Hypertensive Rats, a Model for Attention-Deficit Hyperactivity Disorder.
Cyclin dependent kinase 5
Methylphenidate
Synaptosomal-associated protein 25
Syntaxin 1A
Tropomyosin receptor kinase B
Journal
Psychiatry investigation
ISSN: 1738-3684
Titre abrégé: Psychiatry Investig
Pays: Korea (South)
ID NLM: 101242994
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
received:
29
11
2017
accepted:
22
04
2019
entrez:
30
7
2019
pubmed:
30
7
2019
medline:
30
7
2019
Statut:
ppublish
Résumé
Synaptic vesicle mobilization and neurite outgrowth regulation molecules were examined in modulation of effects of methylphenidate (MPH) in Spontaneous Hypertensive Rats (SHRs), a model for attention-deficit hyperactivity disorder (ADHD). We compared the changes in the protein expression level of Cyclin dependent kinase 5 (Cdk5) and molecular substrates of Cdk5; tropomyosin receptor kinase B (TrkB), syntaxin 1A (STX1A) and synaptosomal-associated protein 25 (SNAP25). Comparisons were made in prefrontal cortex of vehicle (distilled water i.p. for 7 days)-treated SHRs, vehicle-treated Wistar Kyoto Rats (WKYs) and MPH (2 mg/kg i.p. for 7 days) treated SHRs. The Cdk5 level of vehicle-treated SHRs was significantly decreased compared to the Cdk5 level of vehicle-treated WKY rats, but was restored to the expression level of vehicle-treated WKYs in MPH-treated SHR. The ratio of p25/p35 was significantly decreased in MPH-treated SHR compared to vehicle-treated SHR. Moreover, TrkB, STX1A and SNAP25 of vehicle-treated SHRs were significantly decreased compared to vehicle-treated WKY rats, but were restored to the expression level of vehicle-treated WKYs in MPH-treated SHR. The results show that Cdk5, TrkB, STX1A, and SNAP25 were involved in the modulation of MPH effects in prefrontal cortex of SHRs and play important role in treatment of ADHD.
Identifiants
pubmed: 31352739
pii: pi.2019.04.22
doi: 10.30773/pi.2019.04.22
pmc: PMC6664221
doi:
Types de publication
Journal Article
Langues
eng
Pagination
558-564Subventions
Organisme : Ministry of Health and Welfare
ID : A120013
Organisme : National Center for Mental Health
ID : 2017-08
Références
Neuron. 1999 Oct;24(2):401-14
pubmed: 10571233
Neurosci Biobehav Rev. 2000 Jan;24(1):31-9
pubmed: 10654658
Nature. 2000 May 18;405(6784):360-4
pubmed: 10830966
J Biol Chem. 2002 May 10;277(19):16576-84
pubmed: 11867620
Nat Rev Neurosci. 2002 Aug;3(8):617-28
pubmed: 12154363
Jpn Circ J. 1963 Mar;27:282-93
pubmed: 13939773
Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2191-6
pubmed: 14769920
J Neurosci. 2004 Oct 13;24(41):8994-9004
pubmed: 15483118
J Neurosci. 1992 Jul;12(7):2865-74
pubmed: 1613559
J Clin Psychiatry. 2006;67 Suppl 8:13-20
pubmed: 16961425
PLoS Biol. 2007 Apr;5(4):e63
pubmed: 17341134
Arch Pediatr Adolesc Med. 2007 Sep;161(9):857-64
pubmed: 17768285
Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19649-54
pubmed: 18024590
Mol Pharmacol. 2008 Oct;74(4):1101-8
pubmed: 18617632
Am J Med Genet B Neuropsychiatr Genet. 2008 Dec 5;147B(8):1554-63
pubmed: 18937310
Mol Endocrinol. 2009 Aug;23(8):1193-202
pubmed: 19460862
Neuropharmacology. 2009 Dec;57(7-8):619-26
pubmed: 19698722
J Atten Disord. 2011 Jul;15(5):392-402
pubmed: 20065072
J Neurochem. 2010 Jul;114(1):203-14
pubmed: 20403084
Biol Psychiatry. 2010 Dec 15;68(12):1163-71
pubmed: 20832057
Curr Protoc Neurosci. 2011 Jan;Chapter 9:Unit9.35
pubmed: 21207367
Curr Top Behav Neurosci. 2012;9:301-15
pubmed: 21487952
Behav Brain Funct. 2012 Feb 28;8(1):10
pubmed: 22369105
Neuropharmacology. 2012 Dec;63(8):1327-34
pubmed: 22960443
PLoS One. 2013 Apr 12;8(4):e60274
pubmed: 23593184
Front Cell Neurosci. 2015 Oct 07;9:394
pubmed: 26500496
Neural Plast. 2016;2016:6790743
pubmed: 26819770
Biochem Biophys Res Commun. 2016 Sep 2;477(4):932-936
pubmed: 27402274
Sci Rep. 2017 Jul 28;7(1):6828
pubmed: 28754891
J Neurosci. 1996 May 1;16(9):3104-11
pubmed: 8622140
Nature. 1998 Sep 24;395(6700):347-53
pubmed: 9759724
J Biol Chem. 1999 Feb 12;274(7):4027-35
pubmed: 9933594