Probe-based optical fiberscopy for the direct observation of peripheral pulmonary lesions.
Aged
Aged, 80 and over
Bronchi
/ pathology
Bronchoscopy
Constriction, Pathologic
Endosonography
/ instrumentation
Female
Fiber Optic Technology
/ instrumentation
Humans
Lung
/ blood supply
Lung Diseases
/ metabolism
Lung Neoplasms
/ blood supply
Male
Middle Aged
Mucus
/ metabolism
Neovascularization, Pathologic
/ pathology
Optical Fibers
Prospective Studies
Bronchoscopy
Endobronchial ultrasonography
Peripheral pulmonary lesions
Probe-based optical fiberscopy
Journal
Respiratory investigation
ISSN: 2212-5353
Titre abrégé: Respir Investig
Pays: Netherlands
ID NLM: 101581124
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
28
02
2019
revised:
10
06
2019
accepted:
12
06
2019
pubmed:
30
7
2019
medline:
17
3
2020
entrez:
30
7
2019
Statut:
ppublish
Résumé
Peripheral pulmonary lesions are rarely observed directly before transbronchial biopsy. This study aimed to characterize the differences between malignant and benign peripheral pulmonary lesions according to the findings of direct observation using probe-based optical fiberscopy. Thirty patients who underwent probe-based optical fiberscopy in combination with bronchoscopy using endobronchial ultrasonography with a guide sheath for the evaluation of peripheral pulmonary lesions were prospectively included in this study. The patients were divided into the malignant and benign groups according to their final diagnosis. The findings of probe-based optical fiberscopy in the two groups were compared. The numbers of patients who were diagnosed using histological or bacteriological analyses via bronchoscopic sampling in the malignant and benign groups were 20/23 (87.0%) and 2/7 (28.6%), respectively. On probe-based optical fiberscopy, angiogenesis and vascular engorgement were observed only in the malignant group. The disappearance of subepithelial microvessel transparency and presence of bronchiolar stenosis were observed more frequently in the malignant group (78.3% and 60.9%) than in the benign group (28.6% and 28.6%), whereas increased mucus secretion was observed more frequently in the benign group (71.4%) than in the malignant group (8.7%). These results suggest that the findings of direct observation using probe-based optical fiberscopy are useful for differentiating malignant from benign peripheral pulmonary lesions. UMIN-CTR; UMIN000018796; URL: https://www.umin.ac.jp/ctr/index.htm.
Sections du résumé
BACKGROUND
BACKGROUND
Peripheral pulmonary lesions are rarely observed directly before transbronchial biopsy. This study aimed to characterize the differences between malignant and benign peripheral pulmonary lesions according to the findings of direct observation using probe-based optical fiberscopy.
METHODS
METHODS
Thirty patients who underwent probe-based optical fiberscopy in combination with bronchoscopy using endobronchial ultrasonography with a guide sheath for the evaluation of peripheral pulmonary lesions were prospectively included in this study. The patients were divided into the malignant and benign groups according to their final diagnosis. The findings of probe-based optical fiberscopy in the two groups were compared.
RESULTS
RESULTS
The numbers of patients who were diagnosed using histological or bacteriological analyses via bronchoscopic sampling in the malignant and benign groups were 20/23 (87.0%) and 2/7 (28.6%), respectively. On probe-based optical fiberscopy, angiogenesis and vascular engorgement were observed only in the malignant group. The disappearance of subepithelial microvessel transparency and presence of bronchiolar stenosis were observed more frequently in the malignant group (78.3% and 60.9%) than in the benign group (28.6% and 28.6%), whereas increased mucus secretion was observed more frequently in the benign group (71.4%) than in the malignant group (8.7%).
CONCLUSIONS
CONCLUSIONS
These results suggest that the findings of direct observation using probe-based optical fiberscopy are useful for differentiating malignant from benign peripheral pulmonary lesions.
TRIAL REGISTRY
BACKGROUND
UMIN-CTR; UMIN000018796; URL: https://www.umin.ac.jp/ctr/index.htm.
Identifiants
pubmed: 31353288
pii: S2212-5345(19)30066-8
doi: 10.1016/j.resinv.2019.06.006
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
481-489Informations de copyright
Copyright © 2019 The Japanese Respiratory Society. Published by Elsevier B.V. All rights reserved.