Sperm parameters quality and reproductive effects of methanolic extract of Alchornea cordifolia leaves on senescent male rats.
Aging
/ physiology
Animals
Dose-Response Relationship, Drug
Epididymis
/ drug effects
Euphorbiaceae
/ chemistry
Fertility
/ drug effects
Male
Methanol
/ chemistry
Models, Animal
Plant Extracts
/ administration & dosage
Plant Leaves
/ chemistry
Rats
Rats, Wistar
Sperm Count
Sperm Motility
/ drug effects
Spermatozoa
/ drug effects
Testis
/ drug effects
Alchornea cordifolia
hormones
sperm motion
spermatogenesis
Journal
Andrologia
ISSN: 1439-0272
Titre abrégé: Andrologia
Pays: Germany
ID NLM: 0423506
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
09
03
2019
revised:
23
05
2019
accepted:
28
05
2019
pubmed:
30
7
2019
medline:
15
2
2020
entrez:
30
7
2019
Statut:
ppublish
Résumé
The effect of the methanolic extract of Alchornea cordifolia leaves on the fertility of senescent male rats was assessed in this study. 40 rats received daily distilled water, testosterone, 200 and 400 mg/kg of extract of Alchornea cordifolia. The reproductive organs weight, the gonadotropins, testosterone and cholesterol level, the sperm parameters, histology of the testes and epididymis were assessed. The weight of testes and prostate (400 mg/kg) significantly increased (p < 0.05) as well as the level of FHS (p < 0.001), LH and testosterone (p < 0.01) at a dose of 400 mg/kg, respectively, while the cholesterol decreased at a dose of 200 mg/kg (p < 0.05) and 400 mg/kg (p < 0.01) respectively. The testes and epididymis were full of spermatozoa particularly at a dose of 400 mg/kg. The sperm count and morphology significantly increased at both doses of 200 mg/kg (p < 0.01; p < 0.001) and 400 mg/kg (p < 0.001; p < 0.01) respectively. The sperm motion (PROG, VAP, VSL, VCL) (p < 0.001), (ALH, BCF) (p < 0.05) increased at a dose of 200 mg/kg and decreased at a dose of 400 mg/ kg. The overall results provide the strong evidence of the fertility potential of the methanolic extract of Alchornea cordifolia leaves in senescent male rats.
Substances chimiques
Plant Extracts
0
Methanol
Y4S76JWI15
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13359Subventions
Organisme : Organization for Women in Sciences for the Developing World (OWSD)
ID : 3240274094
Informations de copyright
© 2019 Blackwell Verlag GmbH.
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