BRAF V600E mutant
cladribine
hairy-cell leukemia
monomorphic epitheliotropic intestinal T-cell lymphoma
Journal
OncoTargets and therapy
ISSN: 1178-6930
Titre abrégé: Onco Targets Ther
Pays: New Zealand
ID NLM: 101514322
Informations de publication
Date de publication:
2019
2019
Historique:
received:
18
01
2019
accepted:
03
05
2019
entrez:
30
7
2019
pubmed:
30
7
2019
medline:
30
7
2019
Statut:
epublish
Résumé
Hairy cell leukemia (HCL) is an uncommon B-cell chronic lymphoproliferative disorder whose pathogenesis and recurrence are strictly dependent on the presence of the BRAF V600E mutant. A 65-year-old male presented a monomorphic epitheliotropic intestinal T-cell lymphoma (formerly enteropathy-associated T-cell lymphoma, type II) with HCL not responding to first-line induction with cladribine. The intestinal lymphoma bears the BRAF V600E mutant, which is the molecular hallmark of HCL, being implicated in its pathogenesis. The case is of interest, as it provides the first description of a
Identifiants
pubmed: 31354304
doi: 10.2147/OTT.S202061
pii: 202061
pmc: PMC6590676
doi:
Types de publication
Case Reports
Langues
eng
Pagination
4807-4812Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
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