Combining Diagnostic Imaging and Pathology for Improving Diagnosis and Prognosis of Cancer.


Journal

Contrast media & molecular imaging
ISSN: 1555-4317
Titre abrégé: Contrast Media Mol Imaging
Pays: England
ID NLM: 101286760

Informations de publication

Date de publication:
2019
Historique:
received: 13 03 2019
accepted: 12 06 2019
entrez: 30 7 2019
pubmed: 30 7 2019
medline: 3 7 2020
Statut: epublish

Résumé

In the era of personalized medicine, the management of oncological patients requires a translational and multidisciplinary approach. During early phases of cancer development, biochemical alterations of cell metabolism occur much before the formation of detectable tumour masses. Current molecular imaging techniques, targeted to the study of molecular kinetics, employ molecular tracers capable of detecting cancer lesions with both high sensitivity and specificity while also providing essential information for both prognosis and therapy. On the contrary, complementary and crucial information is provided by histopathological examination and ancillary techniques such as immunohistochemistry. Thus, the successful collaboration between diagnostic imaging and anatomic pathology can represent a fundamental step in the "tortuous" but decisive path towards personalized medicine.

Identifiants

pubmed: 31354394
doi: 10.1155/2019/9429761
pmc: PMC6636452
doi:

Substances chimiques

Technetium 7440-26-8

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

9429761

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Auteurs

Orazio Schillaci (O)

Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Via Montpellier 1, Rome 00133, Italy.
IRCCS Neuromed, Pozzilli, Italy.

Manuel Scimeca (M)

Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Via Montpellier 1, Rome 00133, Italy.
University of San Raffaele, Via di Val Cannuta 247, 00166 Rome, Italy.
Fondazione Umberto Veronesi (FUV), Piazza Velasca 5, 20122 Milano, Italy.

Nicola Toschi (N)

Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Via Montpellier 1, Rome 00133, Italy.
Martinos Center for Biomedical Imaging, Boston, MA, USA.
Harvard Medical School, Boston, MA, USA.

Rita Bonfiglio (R)

Department of Experimental Medicine, University "Tor Vergata", Via Montpellier 1, Rome 00133, Italy.

Nicoletta Urbano (N)

Nuclear Medicine, Policlinico "Tor Vergata", Rome, Italy.

Elena Bonanno (E)

Department of Experimental Medicine, University "Tor Vergata", Via Montpellier 1, Rome 00133, Italy.
IRCCS Neuromed Lab, "Diagnostica Medica", "Villa dei Platani", Avellino, Italy.

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