Environmental Stressors on Skin Aging. Mechanistic Insights.

air pollutant inflammation oxidative stress photo-pollution skin aging

Journal

Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923

Informations de publication

Date de publication:
2019
Historique:
received: 20 03 2019
accepted: 11 06 2019
entrez: 30 7 2019
pubmed: 30 7 2019
medline: 30 7 2019
Statut: epublish

Résumé

The skin is the main barrier that protects us against environmental stressors (physical, chemical, and biological). These stressors, combined with internal factors, are responsible for cutaneous aging. Furthermore, they negatively affect the skin and increase the risk of cutaneous diseases, particularly skin cancer. This review addresses the impact of environmental stressors on skin aging, especially those related to general and specific external factors (lifestyle, occupation, pollutants, and light exposure). More specifically, we have evaluated ambient air pollution, household air pollutants from non-combustion sources, and exposure to light (ultraviolet radiation and blue and red light). We approach the molecular pathways involved in skin aging and pathology as a result of exposure to these external environmental stressors. Finally, we reflect on how components of environmental stress can interact with ultraviolet radiation to cause cell damage and the critical importance of knowing the mechanisms to develop new therapies to maintain the skin without damage in old age and to repair its diseases.

Identifiants

pubmed: 31354480
doi: 10.3389/fphar.2019.00759
pmc: PMC6629960
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

759

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Auteurs

Concepcion Parrado (C)

Department of Histology and Pathology, Faculty of Medicine, University of Málaga, Málaga, Spain.

Sivia Mercado-Saenz (S)

Department of Histology and Pathology, Faculty of Medicine, University of Málaga, Málaga, Spain.

Azahara Perez-Davo (A)

Cantabria Labs, Madrid, Spain.

Yolanda Gilaberte (Y)

Dermatology Service, Miguel Servet Hospital, Zaragoza, Spain.

Salvador Gonzalez (S)

Medicine and Medical Specialties Department, Alcala University, Madrid, Spain.

Angeles Juarranz (A)

Biology Department, Sciences School, Autonoma University, Madrid, Spain.

Classifications MeSH