Clinical Importance of CDKN2A Loss and Monosomy 10 in Pilocytic Astrocytoma.
cdkn2a loss
low grade glioma
malignant transformation
pilocytic astrocytoma
pten loss
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
23 May 2019
23 May 2019
Historique:
entrez:
30
7
2019
pubmed:
30
7
2019
medline:
30
7
2019
Statut:
epublish
Résumé
This case of a radiation-naive patient with pilocytic astrocytoma highlights how deletions of CDKN2A (cyclin-dependent kinase Inhibitor 2A) and PTEN (phosphatase and tensin homolog) portended a poor clinical outcome. Pilocytic astrocytomas are grade 1 tumors usually occurring in children and young adults with KIAA1549-BRAF fusion defining the majority of pilocytic astrocytomas. The presence of CDKN2A and PTEN loss may be associated with aggressive biology in pilocytic astrocytoma and further studies should include comprehensive genomics in a larger series of adult pilocytic astrocytoma to evaluate this previously unreported finding. Providers need to be aware of this possibility given the potential for poor outcomes.
Identifiants
pubmed: 31355086
doi: 10.7759/cureus.4726
pmc: PMC6649926
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e4726Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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