Design, Synthesis, and Biological Evaluation of (E)-N'-((1-Chloro-3,4-Dihydronaphthalen-2-yl)Methylene)Benzohydrazide Derivatives as Anti-prostate Cancer Agents.

ADME androgen receptor benzohydrazide molecular docking molecular dynamics prostate cancer

Journal

Frontiers in chemistry
ISSN: 2296-2646
Titre abrégé: Front Chem
Pays: Switzerland
ID NLM: 101627988

Informations de publication

Date de publication:
2019
Historique:
received: 03 04 2019
accepted: 20 06 2019
entrez: 30 7 2019
pubmed: 30 7 2019
medline: 30 7 2019
Statut: epublish

Résumé

Prostate Cancer (PCa) is the most frequently diagnosed cancer in men in their late '50s. PCa growth is mainly due to the activation of the androgen receptor by androgens. The treatment for PCa may involve surgery, hormonal therapy, and oral chemotherapeutic drugs. A structural based molecular docking approach revealed the findings of

Identifiants

pubmed: 31355179
doi: 10.3389/fchem.2019.00474
pmc: PMC6636335
doi:

Types de publication

Journal Article Retracted Publication

Langues

eng

Pagination

474

Commentaires et corrections

Type : ErratumIn
Type : RetractionIn

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Auteurs

H A Arjun (HA)

Drug Discovery Lab, Department of Chemistry, Annamalai University, Chidambaram, India.

Ramakrishnan Elancheran (R)

Drug Discovery Lab, Department of Chemistry, Annamalai University, Chidambaram, India.

N Manikandan (N)

Department of Pharmacology, PSG College of Pharmacy, Coimbatore, India.

K Lakshmithendral (K)

Drug Discovery Lab, Department of Chemistry, Annamalai University, Chidambaram, India.

Muthiah Ramanathan (M)

Department of Pharmacology, PSG College of Pharmacy, Coimbatore, India.

Atanu Bhattacharjee (A)

Computational Biology Laboratory, Department of Biotechnology & Bioinformatics, North Eastern Hill University, Shillong, India.

N K Lokanath (NK)

Department of Physics, University of Mysore, Mysore, India.

Senthamaraikannan Kabilan (S)

Drug Discovery Lab, Department of Chemistry, Annamalai University, Chidambaram, India.

Classifications MeSH