Catching Lipid Droplet Contacts by Proteomics.
contact site
lipid droplet
nonalcoholic fatty liver disease
phosphoproteome
proteomics
steatosis
Journal
Contact (Thousand Oaks (Ventura County, Calif.))
ISSN: 2515-2564
Titre abrégé: Contact (Thousand Oaks)
Pays: United States
ID NLM: 101729710
Informations de publication
Date de publication:
01 Jan 2019
01 Jan 2019
Historique:
entrez:
30
7
2019
pubmed:
30
7
2019
medline:
30
7
2019
Statut:
ppublish
Résumé
Lipid droplets (LDs), important organelles for energy storage and involved in the development of metabolic disorders, are extremely dynamic and interact with many other cellular compartments to orchestrate lipid metabolism. Little is known about how these organelle contacts are changed according to cellular needs and functions under different metabolic and pathological conditions and which proteins regulate this. Here, we summarize recent exciting discoveries about the reorganization of organelle contacts in steatotic liver, including the identification of novel LD contact site proteins in cell lines and in animals. We also discuss state of the art proteomics workflows that enable the characterization of LD-organelle contacts and tethering proteins and give an outlook how this can inform obesity research.
Identifiants
pubmed: 31355355
doi: 10.1177/2515256419859186
pmc: PMC6660307
mid: EMS83774
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2515256419859186Subventions
Organisme : European Research Council
ID : 318987
Pays : International
Déclaration de conflit d'intérêts
Declaration of Conflicting Interests The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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