Gadolinium-based contrast agents: From gadolinium complexes to colloidal systems.
Gadolinium
Gadolinium nanoparticles
Hybrid polyion complexes
MRI
Magnetic resonance imaging
Relaxivity
Journal
International journal of pharmaceutics
ISSN: 1873-3476
Titre abrégé: Int J Pharm
Pays: Netherlands
ID NLM: 7804127
Informations de publication
Date de publication:
05 Oct 2019
05 Oct 2019
Historique:
received:
30
03
2019
revised:
16
07
2019
accepted:
25
07
2019
pubmed:
30
7
2019
medline:
31
1
2020
entrez:
30
7
2019
Statut:
ppublish
Résumé
Nowadays, most of the clinically used contrast agents are based on the use of gadolinium molecular complexes like Dotarem®, Magnevist®…. Nevertheless, developing new gadolinium based contrast agents with enhanced relaxivity properties while avoiding gadolinium release in human tissue is still of paramount importance. We describe here two promising families of contrast agents which meets these criteria and compared their properties to the ones of clinically used Gd complexes. The first one is based on contrast agents obtained by covalent or non-covalent interactions of gadolinium molecular complexes with polymers, nanoparticles or liposomes. The second family is based on the formation of gadolinium particles (Gd
Identifiants
pubmed: 31356957
pii: S0378-5173(19)30621-0
doi: 10.1016/j.ijpharm.2019.118577
pii:
doi:
Substances chimiques
Colloids
0
Contrast Media
0
Polymers
0
Gadolinium
AU0V1LM3JT
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
118577Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.