Synthesis, pharmacological and structural studies of 5-substituted-3-(1-arylmethyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as multi-target ligands of aminergic GPCRs.
Animal Migration
/ drug effects
Animals
Antipsychotic Agents
/ chemical synthesis
CHO Cells
Cricetulus
Disease Models, Animal
Dose-Response Relationship, Drug
HEK293 Cells
Humans
Indoles
/ chemical synthesis
Ligands
Male
Mice
Molecular Structure
Receptors, G-Protein-Coupled
/ antagonists & inhibitors
Structure-Activity Relationship
Journal
European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510
Informations de publication
Date de publication:
15 Oct 2019
15 Oct 2019
Historique:
received:
31
05
2019
revised:
03
07
2019
accepted:
17
07
2019
pubmed:
30
7
2019
medline:
24
12
2019
entrez:
30
7
2019
Statut:
ppublish
Résumé
Schizophrenia is a complex disease with not fully understood pathomechanism, involving many neurotransmitters and their receptors. This is why it is best treated with multi-target drugs, such as second generation antipsychotics. Here we present 5-substituted-3-(1-arylmethyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles (1-20) which are ligands of dopamine D
Identifiants
pubmed: 31357129
pii: S0223-5234(19)30671-3
doi: 10.1016/j.ejmech.2019.07.050
pii:
doi:
Substances chimiques
Antipsychotic Agents
0
Indoles
0
Ligands
0
Receptors, G-Protein-Coupled
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
673-689Informations de copyright
Copyright © 2019 Elsevier Masson SAS. All rights reserved.