Glutathione Transferase P1-1 an Enzyme Useful in Biomedicine and as Biomarker in Clinical Practice and in Environmental Pollution.
Animals
Biomarkers
/ blood
Environmental Exposure
/ adverse effects
Environmental Monitoring
/ methods
Environmental Pollutants
/ adverse effects
Erythrocytes
/ drug effects
Glutathione S-Transferase pi
/ blood
Health Status
Health Status Indicators
Humans
Oxidative Stress
/ drug effects
Predictive Value of Tests
Risk Assessment
Risk Factors
biomarker
cancer
chronic kidney disease
environmental pollution
glutathione
glutathione transferase
hemodialysis
kidney transplantation
liver disease
neurodegenerative disease
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
27 Jul 2019
27 Jul 2019
Historique:
received:
28
06
2019
revised:
19
07
2019
accepted:
23
07
2019
entrez:
31
7
2019
pubmed:
31
7
2019
medline:
21
1
2020
Statut:
epublish
Résumé
Glutathione transferase P1-1 (GSTP1-1) is expressed in some human tissues and is abundant in mammalian erythrocytes (here termed e-GST). This enzyme is able to detoxify the cell from endogenous and exogenous toxic compounds by using glutathione (GSH) or by acting as a ligandin. This review collects studies that propose GSTP1-1 as a useful biomarker in different fields of application. The most relevant studies are focused on GSTP1-1 as a biosensor to detect blood toxicity in patients affected by kidney diseases. In fact, this detoxifying enzyme is over-expressed in erythrocytes when unusual amounts of toxins are present in the body. Here we review articles concerning the level of GST in chronic kidney disease patients, in maintenance hemodialysis patients and to assess dialysis adequacy. GST is also over-expressed in autoimmune disease like scleroderma, and in kidney transplant patients and it may be used to check the efficiency of transplanted kidneys. The involvement of GSTP in the oxidative stress and in other human pathologies like cancer, liver and neurodegenerative diseases, and psychiatric disorders is also reported. Promising applications of e-GST discussed in the present review are its use for monitoring human subjects living in polluted areas and mammals for veterinary purpose.
Identifiants
pubmed: 31357662
pii: nu11081741
doi: 10.3390/nu11081741
pmc: PMC6723968
pii:
doi:
Substances chimiques
Biomarkers
0
Environmental Pollutants
0
GSTP1 protein, human
EC 2.5.1.18
Glutathione S-Transferase pi
EC 2.5.1.18
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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