The Effect of Positive End-Expiratory Pressure on Lung Micromechanics Assessed by Synchrotron Radiation Computed Tomography in an Animal Model of ARDS.

ARDS VILI alveoli kinetics recruitment synchrotron radiation computed tomography

Journal

Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588

Informations de publication

Date de publication:
28 Jul 2019
Historique:
received: 25 06 2019
revised: 17 07 2019
accepted: 25 07 2019
entrez: 31 7 2019
pubmed: 31 7 2019
medline: 31 7 2019
Statut: epublish

Résumé

Modern ventilatory strategies are based on the assumption that lung terminal airspaces act as isotropic balloons that progressively accommodate gas. Phase contrast synchrotron radiation computed tomography (PCSRCT) has recently challenged this concept, showing that in healthy lungs, deflation mechanisms are based on the sequential de-recruitment of airspaces. Using PCSRCT scans in an animal model of acute respiratory distress syndrome (ARDS), this study examined whether the numerosity (ASnum) and dimension (ASdim) of lung airspaces change during a deflation maneuver at decreasing levels of positive end-expiratory pressure (PEEP) at 12, 9, 6, 3, and 0 cmH

Identifiants

pubmed: 31357677
pii: jcm8081117
doi: 10.3390/jcm8081117
pmc: PMC6723999
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Swedish Council of Research (Vetenskapsrådet)
ID : K2015-99X-22731-01-4

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Auteurs

Gaetano Scaramuzzo (G)

Department of Morphology, Surgery and Experimental Medicine, Ferrara University, 44121 Ferrara, Italy.
Hedenstierna Laboratory, Department of Surgical Sciences, Uppsala University, 75185 Uppsala, Sweden.

Ludovic Broche (L)

Hedenstierna Laboratory, Department of Surgical Sciences, Uppsala University, 75185 Uppsala, Sweden.

Mariangela Pellegrini (M)

Hedenstierna Laboratory, Department of Surgical Sciences, Uppsala University, 75185 Uppsala, Sweden.
Department of Anesthesia and Intensive Care, Uppsala University Hospital, 75185 Uppsala, Sweden.

Liisa Porra (L)

Department of Physics, University of Helsinki, FI-00014 Helsinki, Finland.
Helsinki University Hospital, FI-00029 Helsinki, Finland.

Savino Derosa (S)

Department of Emergency and Organ Transplant, Bari University, 70124 Bari, Italy.

Angela Principia Tannoia (AP)

Department of Emergency and Organ Transplant, Bari University, 70124 Bari, Italy.

Andrea Marzullo (A)

Department of Emergency and Organ Transplant, Bari University, 70124 Bari, Italy.

João Batista Borges (JB)

Centre for Human and Applied Physiological Sciences, Faculty of Sciences and Medicine, King's College, London WC2R 2LS, UK.

Sam Bayat (S)

The European Synchrotron Radiation Facility, 38043 Grenoble, France.
INSERM UA7, Synchrotron Radiation for Biomedicine (STROBE) Laboratory, University of Grenoble Alpes, 38043 Grenoble, France.

Alberto Bravin (A)

The European Synchrotron Radiation Facility, 38043 Grenoble, France.

Anders Larsson (A)

Hedenstierna Laboratory, Department of Surgical Sciences, Uppsala University, 75185 Uppsala, Sweden.

Gaetano Perchiazzi (G)

Hedenstierna Laboratory, Department of Surgical Sciences, Uppsala University, 75185 Uppsala, Sweden. gaetano.perchiazzi@surgsci.uu.se.
Department of Anesthesia and Intensive Care, Uppsala University Hospital, 75185 Uppsala, Sweden. gaetano.perchiazzi@surgsci.uu.se.

Classifications MeSH