A Randomized Double-Blind, Cross-Over Trial of very Low-Calorie Diet in Overweight Migraine Patients: A Possible Role for Ketones?
attacks frequency
ketone bodies
ketosis
low-calorie
low-carbohydrate
migraine
weight loss
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
28 Jul 2019
28 Jul 2019
Historique:
received:
04
06
2019
revised:
26
07
2019
accepted:
26
07
2019
entrez:
31
7
2019
pubmed:
31
7
2019
medline:
21
1
2020
Statut:
epublish
Résumé
Here we aimed at determining the therapeutic effect of a very low-calorie diet in overweight episodic migraine patients during a weight-loss intervention in which subjects alternated randomly between a very low-calorie ketogenic diet (VLCKD) and a very low-calorie non-ketogenic diet (VLCnKD) each for one month. In a nutritional program, 35 overweight obese migraine sufferers were allocated blindly to 1-month successive VLCKD or VLCnKD in random order (VLCKD-VLCnKD or VLCnKD-VLCD). The primary outcome measure was the reduction of migraine days each month compared to a 1-month pre-diet baseline. Secondary outcome measures were 50% responder rate for migraine days, reduction of monthly migraine attacks, abortive drug intake and body mass index (BMI) change. Only data from the intention-to-treat cohort (
Identifiants
pubmed: 31357685
pii: nu11081742
doi: 10.3390/nu11081742
pmc: PMC6722531
pii:
doi:
Substances chimiques
Analgesics
0
Types de publication
Clinical Trial, Phase II
Comparative Study
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Références
Epilepsy Res. 2002 Apr;49(2):99-107
pubmed: 12049798
Am J Clin Nutr. 2001 Nov;74(5):579-84
pubmed: 11684524
Brain Sci. 2018 Aug 08;8(8):
pubmed: 30096755
Expert Rev Neurother. 2015 Jun;15(6):621-8
pubmed: 25994046
J Neurochem. 2007 Jun;101(5):1316-26
pubmed: 17403035
EFSA J. 2021 Apr 15;19(4):e06494
pubmed: 33889217
Front Neurol. 2018 Feb 12;9:64
pubmed: 29483892
Trials. 2019 Jan 17;20(1):61
pubmed: 30654835
J Headache Pain. 2013 Jul 30;14:65
pubmed: 23899115
Continuum (Minneap Minn). 2013 Jun;19(3 Epilepsy):756-66
pubmed: 23739109
Am J Gastroenterol. 1992 Jan;87(1):6-15
pubmed: 1728126
Biomed Res Int. 2014;2014:420858
pubmed: 24800223
J Headache Pain. 2016;17:58
pubmed: 27245682
Obes Res. 2001 Nov;9 Suppl 4:295S-301S
pubmed: 11707557
Front Psychol. 2015 Feb 02;6:27
pubmed: 25698989
Neurology. 2006 Feb 28;66(4):545-50
pubmed: 16354886
Prostaglandins Leukot Essent Fatty Acids. 2004 Mar;70(3):253-64
pubmed: 14769484
Endocrine. 2014 Dec;47(3):793-805
pubmed: 24584583
Neurology. 1994 Apr;44(4):666-9
pubmed: 8164822
J Headache Pain. 2018 Jul 5;19(1):49
pubmed: 29978429
Metabolism. 2018 Feb;79:83-96
pubmed: 29223678
J Cereb Blood Flow Metab. 2013 Feb;33(2):191-5
pubmed: 22968322
J Am Coll Nutr. 1985;4(4):411-9
pubmed: 3900179
Curr Pain Headache Rep. 2018 Apr 4;22(5):36
pubmed: 29619630
Nutr Metab (Lond). 2016 Nov 4;13:77
pubmed: 27822291
Headache. 2006 Jan;46(1):182
pubmed: 16412174
Cephalalgia. 2005 Aug;25(8):567-74
pubmed: 16033381
Clin Endocrinol Metab. 1983 Jul;12(2):359-79
pubmed: 6347450
Headache. 2011 Jul-Aug;51(7):1140-8
pubmed: 21649653
Nutr Diabetes. 2016 Sep 19;6(9):e230
pubmed: 27643725
Ann Neurol. 1978 Apr;3(4):331-37
pubmed: 666275
Metabolism. 1975 Jan;24(1):23-33
pubmed: 234169
Eur J Neurol. 2015 Jan;22(1):170-7
pubmed: 25156013
BMC Neurol. 2019 Jun 22;19(1):136
pubmed: 31228957
Cephalalgia. 2013 Jul;33(9):629-808
pubmed: 23771276
Funct Neurol. 2013 Oct-Dec;28(4):305-8
pubmed: 24598400
Cephalalgia. 2008 May;28(5):484-95
pubmed: 18294250
J Clin Invest. 1969 Mar;48(3):574-83
pubmed: 5773093
Biomed Pharmacother. 1996;50(2):71-8
pubmed: 8761712
Neuroscience. 2007 Mar 2;145(1):256-64
pubmed: 17240074