β-Amyrin Ameliorates Alzheimer's Disease-Like Aberrant Synaptic Plasticity in the Mouse Hippocampus.
Alzheimer's disease
Amyloid β
Synaptic plasticity
β-amyrin
Journal
Biomolecules & therapeutics
ISSN: 1976-9148
Titre abrégé: Biomol Ther (Seoul)
Pays: Korea (South)
ID NLM: 101472832
Informations de publication
Date de publication:
01 Jan 2020
01 Jan 2020
Historique:
received:
08
02
2019
revised:
13
06
2019
accepted:
17
06
2019
pubmed:
31
7
2019
medline:
31
7
2019
entrez:
31
7
2019
Statut:
ppublish
Résumé
Alzheimer's disease (AD) is a progressive and most frequently diagnosed neurodegenerative disorder. However, there is still no drug preventing the progress of this disorder. β-Amyrin, an ingredient of the surface wax of tomato fruit and dandelion coffee, is previously reported to ameliorate memory impairment induced by cholinergic dysfunction. Therefore, we tested whether β-amyrin can prevent AD-like pathology. β-Amyrin blocked amyloid β (Aβ)-induced long-term potentiation (LTP) impairment in the hippocampal slices. Moreover, β-amyrin improved Aβ-induced suppression of phosphatidylinositol-3-kinase (PI3K)/Akt signaling. LY294002, a PI3K inhibitor, blocked the effect of β-amyrin on Aβ-induced LTP impairment. In
Identifiants
pubmed: 31357749
pii: biomolther.2019.024
doi: 10.4062/biomolther.2019.024
pmc: PMC6939697
doi:
Types de publication
Journal Article
Langues
eng
Pagination
74-82Références
Biol Pharm Bull. 2014;37(7):1207-13
pubmed: 24989012
Lipids Health Dis. 2012 Aug 06;11:98
pubmed: 22867128
J Anat. 2011 Jul;219(1):78-89
pubmed: 21323664
Phytochem Rev. 2012 Jun;11(2-3):263-284
pubmed: 23519009
Pharmacol Ther. 2015 Apr;148:114-31
pubmed: 25435019
Lancet Neurol. 2007 Aug;6(8):734-46
pubmed: 17616482
Br J Pharmacol. 2015 May;172(9):2354-68
pubmed: 25560396
J Basic Clin Pharm. 2016 Mar;7(2):27-31
pubmed: 27057123
FASEB J. 2009 Mar;23(3):739-50
pubmed: 19001528
J Biol Chem. 2015 Nov 20;290(47):28540-58
pubmed: 26420483
Sci Rep. 2015 Jan 21;5:7912
pubmed: 25604482
Brain Pathol. 2016 Jan;26(1):62-74
pubmed: 25763997
J Neurosci Res. 2009 Aug 1;87(10):2297-307
pubmed: 19301428
Psychopharmacology (Berl). 2019 Apr;236(4):1281-1292
pubmed: 30515523
Pharm Biol. 2014 Nov;52(11):1478-86
pubmed: 25026352
Mol Neurodegener. 2017 Mar 21;12(1):27
pubmed: 28327181
Oncotarget. 2017 Apr 25;8(17):27676-27692
pubmed: 28430602
PLoS One. 2008 Aug 13;3(8):e2935
pubmed: 18698410
Science. 2002 Jul 19;297(5580):353-6
pubmed: 12130773
J Neuroinflammation. 2012 Apr 02;9:62
pubmed: 22472085
Nature. 2002 Apr 4;416(6880):535-9
pubmed: 11932745
Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9959-64
pubmed: 24958880
Alzheimers Res Ther. 2014 Jun 20;6(3):35
pubmed: 25031641
Neurobiol Aging. 2015 Jan;36(1):123-33
pubmed: 25104560
Behav Brain Res. 2015 Sep 15;291:232-236
pubmed: 26026786
Nature. 2014 Jul 17;511(7509):348-52
pubmed: 24896183
Phytomedicine. 2012 Jun 15;19(8-9):682-5
pubmed: 22541636
Front Mol Neurosci. 2017 Jul 04;10:214
pubmed: 28725178
Neuron. 1991 Apr;6(4):487-98
pubmed: 1673054
Neuropharmacology. 2018 Jan;128:282-292
pubmed: 29079294
Biochim Biophys Acta. 2013 Dec;1832(12):1913-21
pubmed: 23816568
Acta Neuropathol. 2015 Feb;129(2):183-206
pubmed: 25604547
J Psychosom Res. 2006 Sep;61(3):311-6
pubmed: 16938507
Nat Neurosci. 2011 May;14(5):545-7
pubmed: 21441921
Mol Neurodegener. 2011 Dec 22;6:85
pubmed: 22192775
Cell Death Dis. 2015 Jun 18;6:e1791
pubmed: 26086964
Eur J Pharmacol. 2014 Jul 5;734:77-82
pubmed: 24726843
J Vis Exp. 2016 Mar 16;(109):null
pubmed: 27023127
J Neurochem. 2002 Dec;83(6):1509-24
pubmed: 12472904
Biochem Biophys Res Commun. 2015 Nov 27;467(4):676-82
pubmed: 26498523
PLoS One. 2014 Jan 23;9(1):e86237
pubmed: 24465980
Br J Pharmacol. 2012 Dec;167(8):1596-608
pubmed: 22646533
Hum Exp Toxicol. 2017 Feb;36(2):113-122
pubmed: 27009110
Curr Alzheimer Res. 2011 Nov;8(7):707-17
pubmed: 21453244
Nature. 2017 Sep 21;549(7672):384-388
pubmed: 28902836
Neurobiol Learn Mem. 2015 May;121:20-9
pubmed: 25838119
Pain. 2011 Aug;152(8):1872-87
pubmed: 21620566
Neurosci Biobehav Rev. 2016 Jun;65:326-40
pubmed: 27044452
Inflammopharmacology. 2014 Dec;22(6):373-85
pubmed: 25300965