Low Birth Weight and Kidney Function in Middle-Aged Men and Women: The Netherlands Epidemiology of Obesity Study.
Academic Medical Centers
Age Factors
Aged
Cohort Studies
Databases, Factual
Disease Progression
Female
Glomerular Filtration Rate
/ physiology
Humans
Infant, Low Birth Weight
Infant, Newborn
Kidney Function Tests
Linear Models
Male
Mendelian Randomization Analysis
Middle Aged
Multivariate Analysis
Netherlands
/ epidemiology
Renal Insufficiency, Chronic
/ diagnosis
Retrospective Studies
Risk Assessment
Self Report
/ statistics & numerical data
Sex Factors
Birth weight
Mendelian randomization
albuminuria
chronic kidney disease (CKD)
delayed effects
eGFR decline
epidemiology
estimated glomerular filtration rate (eGFR)
fetal programming
glomerular mass
intrauterine environment
kidney function
middle age
nephron deficit
prenatal exposure
Journal
American journal of kidney diseases : the official journal of the National Kidney Foundation
ISSN: 1523-6838
Titre abrégé: Am J Kidney Dis
Pays: United States
ID NLM: 8110075
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
10
09
2018
accepted:
03
05
2019
pubmed:
31
7
2019
medline:
9
4
2020
entrez:
31
7
2019
Statut:
ppublish
Résumé
Chronic kidney disease (CKD), defined as estimated glomerular filtration rate (eGFR)<60mL/min/1.73m Retrospective cohort study. 6,671 participants in the Netherlands Epidemiology of Obesity (NEO) Study. Replication study using data for 133,814 participants studied by the CKDGen consortium. Birth weight was self-reported and also based on an instrumental variable, 59 birth weight-associated genetic variants, derived from an independent data source. eGFR at the age of 45 to 65 years. We assessed the association between self-reported birth weight and eGFR in the NEO Study using multivariable linear regression, adjusted for age, sex, education, smoking, and alcohol use. The effect of the instrument on eGFR was estimated using separate 2-sample Mendelian randomization analyses: one using individual data from the NEO cohort and one using summary data from the CKDGen consortium. At baseline, mean eGFR was 86±12.4 (SD) mL/min/1.73m Birth weight was self-reported. Lower birth weight defined using genetic variants was associated with lower eGFRs in Dutch middle-aged adults. However, this finding was not replicated within the CKDGen consortium.
Identifiants
pubmed: 31358312
pii: S0272-6386(19)30773-5
doi: 10.1053/j.ajkd.2019.05.007
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
751-760Informations de copyright
Copyright © 2019 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.