Curcumin inhibits NF-kB and Wnt/β-catenin pathways in cervical cancer cells.
Antineoplastic Agents
/ pharmacology
Apoptosis
/ drug effects
Cell Proliferation
/ drug effects
Curcumin
/ pharmacology
Down-Regulation
/ drug effects
Enzyme Inhibitors
/ pharmacology
Female
Fluorouracil
/ pharmacology
HeLa Cells
Humans
NF-kappa B
/ metabolism
Signal Transduction
/ drug effects
Uterine Cervical Neoplasms
/ metabolism
Wnt Proteins
/ metabolism
Wnt Signaling Pathway
/ drug effects
beta Catenin
/ metabolism
5-Fluorouracil
Cervical cancer
Curcumin
Therapy
Journal
Pathology, research and practice
ISSN: 1618-0631
Titre abrégé: Pathol Res Pract
Pays: Germany
ID NLM: 7806109
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
10
05
2019
revised:
01
07
2019
accepted:
22
07
2019
pubmed:
31
7
2019
medline:
7
3
2020
entrez:
31
7
2019
Statut:
ppublish
Résumé
Curcumin is a natural non-toxic phenol which is isolated from Curcumin longa L. Mounting evidence has revealed the anticancer properties of curcumin in various tumors, but the underlying molecular mechanisms of this suppression in cervical cancer is still remained unclear. Here we assessed the antitumor effects of curcumin compared with 5-Fluorouracil in Hella cells in spheroids models and monolayer cell cultures. The anti-proliferative effects of curcumin and 5-Fluorouracil were as examined in spheroid and monolayer models. The expression levels of Wnt/β-catenin and NF-kB pathways as well as the influence of the cell cycle were evaluated. Curcumin inhibited cell growth in Hella cells through the regulation of NF-kB and Wnt pathways. Also, cells developed a G2/M cell cycle arrest followed by sub-G1 apoptosis with 5-Fluorouracil and curcumin. It was also shown that curcumin either considerably affects the Wnt/β-catenin and NF-kB pathways. We showed that curcumin inhibits invasion and proliferation of cervical cancer cells via impairment of NF-kB and Wnt/β-catenin pathways, proposing further studies on the potential impacts of this compound on cancer therapy.
Identifiants
pubmed: 31358480
pii: S0344-0338(19)30883-0
doi: 10.1016/j.prp.2019.152556
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Enzyme Inhibitors
0
NF-kappa B
0
Wnt Proteins
0
beta Catenin
0
Curcumin
IT942ZTH98
Fluorouracil
U3P01618RT
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
152556Informations de copyright
Copyright © 2019 Elsevier GmbH. All rights reserved.