Serum PlGF and EGF are independent prognostic markers in non-metastatic colorectal cancer.

Aged Biomarkers, Tumor / blood Colorectal Neoplasms / diagnosis Disease-Free Survival Epidermal Growth Factor / blood Female Humans Male Neoplasm Staging Placenta Growth Factor / blood Prognosis Retrospective Studies

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
29 07 2019
Historique:
received: 28 01 2019
accepted: 17 07 2019
entrez: 31 7 2019
pubmed: 31 7 2019
medline: 4 11 2020
Statut: epublish

Résumé

The aim of this study was to determine the prognostic value of circulating angiogenic cytokines in non-metastatic colorectal cancer (CRC) patients. Preoperative serum samples of a training (TC) (n = 219) and a validation cohort (VC) (n = 168) were analyzed via ELISA to determine PlGF, EGF, VEGF, Ang1, PDGF-A, PDGF-B, IL-8 and bFGF levels. In addition, survival was correlated with PlGF and EGF expression measured by microarray and RNAseq in two publicly available, independent cohorts (n = 550 and n = 463, respectively). Prognostic values for overall (OS) and disease-free survival (DFS) were determined using uni- and multivariate Cox proportional hazard analyses. Elevated PlGF is predictive for impaired OS (TC: HR 1.056; p = 0.046; VC: HR 1.093; p = 0.001) and DFS (TC: HR 1.052; p = 0.029; VC: HR 1.091; p = 0.009). Conversely, elevated EGF is associated with favorable DFS (TC: HR 0.998; p = 0.045; VC: HR 0.998; p = 0.018) but not OS (TC: p = 0.201; VC: p = 0.453). None of the other angiogenic cytokines correlated with prognosis. The prognostic value of PlGF (OS + DFS) and EGF (DFS) was confirmed in both independent retrospective cohorts. Serum PlGF and EGF may serve as prognostic markers in non-metastatic CRC.

Identifiants

DOI: 10.1038/s41598-019-47429-5 PMID: 31358848 PMC: PMC6662856
pubmed: 31358848
doi: 10.1038/s41598-019-47429-5
pii: 10.1038/s41598-019-47429-5
pmc: PMC6662856
doi:

Substances chimiques

Biomarkers, Tumor 0
PGF protein, human 0
Placenta Growth Factor 144589-93-5
Epidermal Growth Factor 62229-50-9

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

10921

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Auteurs

Sebastian Schölch (S)

Department of Surgery, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. sebastian.schoelch@umm.de.
Department of Gastrointestinal, Thoracic and Vascular Surgery, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. sebastian.schoelch@umm.de.
German Cancer Consortium, Heidelberg, Germany. sebastian.schoelch@umm.de.
German Cancer Research Center (DKFZ), Heidelberg, Germany. sebastian.schoelch@umm.de.
ORCID: 0000-0003-0012-3177

Andreas Bogner (A)

Department of Gastrointestinal, Thoracic and Vascular Surgery, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
ORCID: 0000-0001-9226-5337

Ulrich Bork (U)

Department of Gastrointestinal, Thoracic and Vascular Surgery, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.

Mohammad Rahbari (M)

Department of Surgery, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
ORCID: 0000-0003-1133-2134

Balázs Győrffy (B)

MTA TTK Lendület Cancer Biomarker Research Group, Magyar Tudósok körútja 2., H-1117, Budapest, Hungary.
Semmelweis University, 2nd Department of Pediatrics, Bókay u. 53-54., H-1083, Budapest, Hungary.

Martin Schneider (M)

German Cancer Consortium, Heidelberg, Germany.
German Cancer Research Center (DKFZ), Heidelberg, Germany.
Department of General, Gastrointestinal and Transplant Surgery, University Hospital Heidelberg, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany.

Christoph Reissfelder (C)

Department of Surgery, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Department of Gastrointestinal, Thoracic and Vascular Surgery, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
German Cancer Consortium, Heidelberg, Germany.
German Cancer Research Center (DKFZ), Heidelberg, Germany.

Jürgen Weitz (J)

Department of Gastrointestinal, Thoracic and Vascular Surgery, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
German Cancer Consortium, Heidelberg, Germany.
German Cancer Research Center (DKFZ), Heidelberg, Germany.

Nuh N Rahbari (NN)

Department of Surgery, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Department of Gastrointestinal, Thoracic and Vascular Surgery, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Serum PlGF and EGF are independent prognostic...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › Serum PlGF and EGF are independent prognostic...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies du rectum › Tumeurs colorectales › Serum PlGF and EGF are independent prognostic...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de survie › Survie sans rechute › Serum PlGF and EGF are independent prognostic...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de la famille de l'EGF › Facteur de croissance épidermique › Serum PlGF and EGF are independent prognostic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Serum PlGF and EGF are independent prognostic...
questionsmedicales.fr › Diagnostic › Pronostic › Stadification tumorale › Serum PlGF and EGF are independent prognostic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de la grossesse › Facteur de croissance placentaire › Serum PlGF and EGF are independent prognostic...
questionsmedicales.fr › Diagnostic › Pronostic › Serum PlGF and EGF are independent prognostic...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Serum PlGF and EGF are independent prognostic...