5-methylcytosine promotes pathogenesis of bladder cancer through stabilizing mRNAs.

5-Methylcytosine / metabolism Animals Carcinoma, Transitional Cell / genetics Gene Expression Regulation / genetics Humans Methyltransferases / genetics Mice RNA, Messenger / genetics Urinary Bladder Neoplasms / genetics Y-Box-Binding Protein 1 / genetics

Journal

Nature cell biology
ISSN: 1476-4679
Titre abrégé: Nat Cell Biol
Pays: England
ID NLM: 100890575

Informations de publication

Date de publication:
08 2019
Historique:
received: 24 09 2018
accepted: 12 06 2019
pubmed: 31 7 2019
medline: 20 11 2019
entrez: 31 7 2019
Statut: ppublish

Résumé

Although 5-methylcytosine (m

Identifiants

DOI: 10.1038/s41556-019-0361-y PMID: 31358969
pubmed: 31358969
doi: 10.1038/s41556-019-0361-y
pii: 10.1038/s41556-019-0361-y
doi:

Substances chimiques

RNA, Messenger 0
Y-Box-Binding Protein 1 0
YBX1 protein, human 0
5-Methylcytosine 6R795CQT4H
Methyltransferases EC 2.1.1.-
NSUN2 protein, human EC 2.1.1.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

978-990

Commentaires et corrections

Type : CommentIn

Auteurs

Xin Chen (X)

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, China.

Ang Li (A)

CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
University of Chinese Academy of Sciences, Beijing, China.

Bao-Fa Sun (BF)

CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
University of Chinese Academy of Sciences, Beijing, China.
Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China.

Ying Yang (Y)

CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
University of Chinese Academy of Sciences, Beijing, China.
Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China.

Ya-Nan Han (YN)

CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
University of Chinese Academy of Sciences, Beijing, China.

Xun Yuan (X)

State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.

Ri-Xin Chen (RX)

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.

Wen-Su Wei (WS)

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, China.

Yanchao Liu (Y)

State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.
ORCID: 0000-0002-6647-8491

Chun-Chun Gao (CC)

CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
University of Chinese Academy of Sciences, Beijing, China.

Yu-Sheng Chen (YS)

CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
University of Chinese Academy of Sciences, Beijing, China.
ORCID: 0000-0001-5292-1301

Mengmeng Zhang (M)

State Key Laboratory of Genetic Engineering, Collaborative Innovation Centre of Genetics and Development, Multiscale Research Institute for Complex Systems, Department of Biochemistry, School of Life Sciences, Fudan University, Shanghai, China.

Xiao-Dan Ma (XD)

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.

Zhuo-Wei Liu (ZW)

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, China.

Jun-Hang Luo (JH)

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.

Cong Lyu (C)

University of Chinese Academy of Sciences, Beijing, China.
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.

Hai-Lin Wang (HL)

University of Chinese Academy of Sciences, Beijing, China.
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.

Jinbiao Ma (J)

State Key Laboratory of Genetic Engineering, Collaborative Innovation Centre of Genetics and Development, Multiscale Research Institute for Complex Systems, Department of Biochemistry, School of Life Sciences, Fudan University, Shanghai, China.
ORCID: 0000-0002-0232-1786

Yong-Liang Zhao (YL)

CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
University of Chinese Academy of Sciences, Beijing, China.
Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China.

Fang-Jian Zhou (FJ)

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, China.

Ying Huang (Y)

State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China. huangy@sibcb.ac.cn.
ORCID: 0000-0002-2806-2874

Dan Xie (D)

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China. xiedan@sysucc.org.cn.
ORCID: 0000-0003-2242-3138

Yun-Gui Yang (YG)

CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China. ygyang@big.ac.cn.
University of Chinese Academy of Sciences, Beijing, China. ygyang@big.ac.cn.
Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China. ygyang@big.ac.cn.
ORCID: 0000-0002-2821-8541

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Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrimidines › Pyrimidinones › Cytosine › 5-Méthyl-cytosine › 5-methylcytosine promotes pathogenesis of...
questionsmedicales.fr › Eucaryotes › Animaux › 5-methylcytosine promotes pathogenesis of...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Carcinomes › Carcinome transitionnel › 5-methylcytosine promotes pathogenesis of...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › 5-methylcytosine promotes pathogenesis of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › 5-methylcytosine promotes pathogenesis of...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › One-carbon group transferases › Methyltransferases › 5-methylcytosine promotes pathogenesis of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › 5-methylcytosine promotes pathogenesis of...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › 5-methylcytosine promotes pathogenesis of...
questionsmedicales.fr › Maladies urogénitales › Maladies urologiques › Tumeurs urologiques › Tumeurs de la vessie urinaire › 5-methylcytosine promotes pathogenesis of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique et à glissière à leucines › Protéines liant les séquences stimulatrices de type CCAAT › Protéine-1 de liaison à la boîte Y › 5-methylcytosine promotes pathogenesis of...