Genome-wide association study of post-traumatic stress disorder reexperiencing symptoms in >165,000 US veterans.
Journal
Nature neuroscience
ISSN: 1546-1726
Titre abrégé: Nat Neurosci
Pays: United States
ID NLM: 9809671
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
27
09
2018
accepted:
11
06
2019
pubmed:
31
7
2019
medline:
7
11
2019
entrez:
31
7
2019
Statut:
ppublish
Résumé
Post-traumatic stress disorder (PTSD) is a major problem among military veterans and civilians alike, yet its pathophysiology remains poorly understood. We performed a genome-wide association study and bioinformatic analyses, which included 146,660 European Americans and 19,983 African Americans in the US Million Veteran Program, to identify genetic risk factors relevant to intrusive reexperiencing of trauma, which is the most characteristic symptom cluster of PTSD. In European Americans, eight distinct significant regions were identified. Three regions had values of P < 5 × 10
Identifiants
pubmed: 31358989
doi: 10.1038/s41593-019-0447-7
pii: 10.1038/s41593-019-0447-7
pmc: PMC6953633
mid: NIHMS1064133
doi:
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1394-1401Subventions
Organisme : CSP VA
ID : CSP #575B
Pays : United States
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