Current and Emerging Methods of Management of Ependymoma.
Cerebellopontine angle
Chemotherapy
Ependymoma
Paediatric
Radiotherapy
Surgery
Journal
Current oncology reports
ISSN: 1534-6269
Titre abrégé: Curr Oncol Rep
Pays: United States
ID NLM: 100888967
Informations de publication
Date de publication:
29 07 2019
29 07 2019
Historique:
entrez:
31
7
2019
pubmed:
31
7
2019
medline:
25
8
2020
Statut:
epublish
Résumé
This review discusses the evidence base behind current and emerging strategies of management of intracranial and spinal ependymomas in children, with a particular focus on aspects of surgical techniques, challenges and complications. The cornerstone of management remains maximal safe resective surgery, which has repeatedly been shown to correlate with improved survival. This is followed by focal conformal radiotherapy, although good results using proton beam therapy, with the potential for diminished side effects, are emerging. The role of chemotherapy remains largely unproven for paediatric ependymoma. Despite optimal management strategies, many children with ependymoma suffer from tumour recurrence. The standard of care for paediatric ependymoma comprises surgery and radiotherapy. Results of ongoing clinical trials will help shape its management in order to leverage our increasingly sophisticated understanding of the genetic drivers behind these tumours into survival benefit for this challenging group of patients.
Identifiants
pubmed: 31359299
doi: 10.1007/s11912-019-0826-y
pii: 10.1007/s11912-019-0826-y
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
78Subventions
Organisme : Department of Health
Pays : United Kingdom
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