Patterned cutaneous hypopigmentation phenotype characterization: A retrospective study in 106 children.
genetics
hypomelanosis of Ito
hypopigmentation
mosaicism
Journal
Pediatric dermatology
ISSN: 1525-1470
Titre abrégé: Pediatr Dermatol
Pays: United States
ID NLM: 8406799
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
pubmed:
31
7
2019
medline:
1
5
2020
entrez:
31
7
2019
Statut:
ppublish
Résumé
Cutaneous patterned hypopigmentation's phenotype is highly variable and may be associated with extracutaneous anomalies. We evaluated the phenotypic and clinical characteristics of patients with cutaneous patterned hypopigmentation to determine whether certain patterns were more likely to be associated with underlying anomalies. The charts of 106 children with cutaneous patterned hypopigmentation were reviewed retrospectively (2007-2018) at Sainte-Justine University Hospital Centre, in Montreal, Canada. Retrieved information included sex, age at diagnosis, phototype, pattern, and distribution of the cutaneous lesions and the presence of extracutaneous findings. Data were recorded on a software tool which collects and analyzes phenotypic information. The predominant types of cutaneous patterned hypopigmentation were along Blaschko's lines in narrow (38.7%) and broad bands (53.8%). Mixed patterns were observed in 22.5% of children. The anterior trunk and posterior trunk were most frequently affected (69% and 56%, respectively). Extracutaneous involvement, especially neurological and developmental, was present in 28.3% of patients and was significantly associated with ≥ 4 involved body sites. Distribution and types of cutaneous patterned hypopigmentation were not predictive of extracutaneous findings, with the exception of multiple sites involvement and possibly centrofacial location and blocklike lesions. Follow-up until school entry should help identify subtler associated extracutaneous anomalies.
Sections du résumé
BACKGROUND
BACKGROUND
Cutaneous patterned hypopigmentation's phenotype is highly variable and may be associated with extracutaneous anomalies.
OBJECTIVE
OBJECTIVE
We evaluated the phenotypic and clinical characteristics of patients with cutaneous patterned hypopigmentation to determine whether certain patterns were more likely to be associated with underlying anomalies.
METHODS
METHODS
The charts of 106 children with cutaneous patterned hypopigmentation were reviewed retrospectively (2007-2018) at Sainte-Justine University Hospital Centre, in Montreal, Canada. Retrieved information included sex, age at diagnosis, phototype, pattern, and distribution of the cutaneous lesions and the presence of extracutaneous findings. Data were recorded on a software tool which collects and analyzes phenotypic information.
RESULTS
RESULTS
The predominant types of cutaneous patterned hypopigmentation were along Blaschko's lines in narrow (38.7%) and broad bands (53.8%). Mixed patterns were observed in 22.5% of children. The anterior trunk and posterior trunk were most frequently affected (69% and 56%, respectively). Extracutaneous involvement, especially neurological and developmental, was present in 28.3% of patients and was significantly associated with ≥ 4 involved body sites.
CONCLUSION
CONCLUSIONS
Distribution and types of cutaneous patterned hypopigmentation were not predictive of extracutaneous findings, with the exception of multiple sites involvement and possibly centrofacial location and blocklike lesions. Follow-up until school entry should help identify subtler associated extracutaneous anomalies.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
869-875Subventions
Organisme : Canadian Dermatology Foundation
Organisme : Lise Bachand Foundation
Organisme : University of Montreal, Division of Dermatology
Informations de copyright
© 2019 Wiley Periodicals, Inc.
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