Evaluation of p16/Ki-67 Dual Staining Compared with HPV Genotyping in Anal Cytology with Diagnosis of ASC-US for Detection of High-Grade Anal Intraepithelial Lesions.
Anal cytology
CINtec
Human Papillomavirus
anal intraepithelial neoplasia
p16/Ki-67
Journal
Journal of cytology
ISSN: 0970-9371
Titre abrégé: J Cytol
Pays: India
ID NLM: 8915204
Informations de publication
Date de publication:
Historique:
entrez:
31
7
2019
pubmed:
31
7
2019
medline:
31
7
2019
Statut:
ppublish
Résumé
Human Anal cytology samples with an ASC-US result ( Detection of HSIL on follow-up specimens (5/22 biopsies; 1/29 cytology samples) was obtained in two out of six cases with p16/Ki-17 versus. five out of six with HPV genotyping alone. Sensitivity and specificity to detect HSIL for p16/Ki-67 was 33% (95% confidence interval [CI] [4; 77]) and 49% (95%CI [34; 64]) versus. 83% (95%CI [36; 99.6]) and 13% (95%CI [5; 27]) for HPV genotyping. Herein, HPV genotyping was more sensitive but less specific than p16/Ki-67 staining for the detection of subsequent HSIL in ASC-US anal cytology. A larger study is required to evaluate the combination of these biomarkers for triage.
Identifiants
pubmed: 31359914
doi: 10.4103/JOC.JOC_131_18
pii: JCytol-36-152
pmc: PMC6592121
doi:
Types de publication
Journal Article
Langues
eng
Pagination
152-156Déclaration de conflit d'intérêts
There are no conflicts of interest.
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