Cardiac assessment in Wilson's disease patients based on electrocardiography and echocardiography examination.
hepatolenticular degeneration
left ventricular diastolic dysfunction
left ventricular hypertrophy
Journal
Archives of medical science : AMS
ISSN: 1734-1922
Titre abrégé: Arch Med Sci
Pays: Poland
ID NLM: 101258257
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
received:
12
01
2017
accepted:
14
05
2017
entrez:
31
7
2019
pubmed:
31
7
2019
medline:
31
7
2019
Statut:
ppublish
Résumé
Wilson's disease (WD) is a rare genetic disorder that leads to impairments in copper metabolism. Patients principally exhibit liver and neuropsychiatric symptoms, but because copper also accumulates in all body organs, other (typically milder) clinical symptoms can occur. To date, cardiac involvement has not been thoroughly investigated in patients with WD. This study aimed to evaluate heart structure and function in patients with WD with commonly available diagnostic methods. We compared 125 WD patients with an age- and sex-matched control group. Patients with WD were grouped according to their dominant symptoms - neurologic or hepatic. All subjects underwent clinical, electrocardiographic (ECG), and echocardiographic examinations. All subjects had sinus rhythm on electrocardiography. The only ECG parameter that differed between patients with WD and the control group was the QRS prolongation (92.0 vs. 86.4 ms; Heart involvement in WD was manifested mainly by mild left ventricular hypertrophy and subclinical changes in diastolic function, particularly in the patients with the neurologic form of disease.
Identifiants
pubmed: 31360180
doi: 10.5114/aoms.2017.69728
pii: 30498
pmc: PMC6657248
doi:
Types de publication
Journal Article
Langues
eng
Pagination
857-864Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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