Sensorimotor, language, and working memory representation within the human cerebellum.
Adult
Brain Mapping
Cerebellum
/ diagnostic imaging
Cognition
/ physiology
Female
Functional Laterality
Humans
Language
Magnetic Resonance Imaging
Male
Memory, Short-Term
/ physiology
Photic Stimulation
Physical Stimulation
Psychomotor Performance
/ physiology
Sensation
/ physiology
Vibration
Young Adult
cerebellum
fMRI
language
sensorimotor
working memory
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
01 11 2019
01 11 2019
Historique:
received:
26
01
2019
revised:
10
07
2019
accepted:
12
07
2019
pubmed:
31
7
2019
medline:
15
4
2020
entrez:
31
7
2019
Statut:
ppublish
Résumé
The cerebellum is involved in a wide range of behaviours. A key organisational principle from animal studies is that somatotopically corresponding sensory input and motor output reside in the same cerebellar cortical areas. However, compelling evidence for a similar arrangement in humans and whether it extends to cognitive functions is lacking. To address this, we applied cerebellar optimised whole-brain functional MRI in 20 healthy subjects. To assess spatial overlap within the sensorimotor and cognitive domains, we recorded activity to a sensory stimulus (vibrotactile) and a motor task; the Sternberg verbal working memory (VWM) task; and a verb generation paradigm. Consistent with animal data, sensory and motor activity overlapped with a somatotopic arrangement in ipsilateral areas of the anterior and posterior cerebellum. During the maintenance phase of the Sternberg task, a positive linear relationship between VWM load and activity was observed in right Lobule VI, extending into Crus I bilaterally. Articulatory movement gave rise to bilateral activity in medial Lobule VI. A conjunction of two independent language tasks localised activity during verb generation in right Lobule VI-Crus I, which overlapped with activity during VWM. These results demonstrate spatial compartmentalisation of sensorimotor and cognitive function in the human cerebellum, with each area involved in more than one aspect of a given behaviour, consistent with an integrative function. Sensorimotor localisation was uniform across individuals, but the representation of cognitive tasks was more variable, highlighting the importance of individual scans for mapping higher order functions within the cerebellum.
Identifiants
pubmed: 31361075
doi: 10.1002/hbm.24733
pmc: PMC6865458
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4732-4747Subventions
Organisme : Medical Research Council
ID : G0700238
Pays : United Kingdom
Organisme : U.K. Medical Research Council
ID : G0700238
Pays : International
Organisme : Action Medical Research
ID : SP4619
Pays : International
Informations de copyright
© 2019 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc.
Références
J Neurophysiol. 2011 Jun;105(6):3042-53
pubmed: 21471398
Behav Neurol. 2010;23(1-2):51-63
pubmed: 20714061
Brain. 1996 Jun;119 ( Pt 3):1023-9
pubmed: 8673479
Cerebellum. 2016 Jun;15(3):322-35
pubmed: 26202670
Neuroimage. 2009 Oct 15;48(1):63-72
pubmed: 19573611
Exp Brain Res. 1971 Jul 26;13(1):54-77
pubmed: 4936709
Neuroimage. 2001 Jan;13(1):218-29
pubmed: 11133324
Somatosens Mot Res. 2005 Dec;22(4):281-97
pubmed: 16503581
Magn Reson Med. 2002 Jun;47(6):1202-10
pubmed: 12111967
Nat Neurosci. 2014 Sep;17(9):1233-9
pubmed: 25064850
Neuroimage. 2011 Jan 15;54(2):1465-75
pubmed: 20884358
Trends Cogn Sci. 1998 Sep 1;2(9):338-47
pubmed: 21227230
J Exp Psychol Learn Mem Cogn. 2007 May;33(3):615-622
pubmed: 17470009
J Neurosci. 1997 Dec 15;17(24):9675-85
pubmed: 9391022
Cerebellum. 2014 Jun;13(3):354-61
pubmed: 24338673
Nat Neurosci. 2009 Jun;12(6):718-24
pubmed: 19471271
Brain Res Cogn Brain Res. 2004 Nov;21(3):377-87
pubmed: 15511653
Science. 1992 Jan 31;255(5044):556-9
pubmed: 1736359
Neuroimage. 2005 Aug 1;27(1):201-9
pubmed: 15921935
Neurosci Lett. 2006 Nov 27;409(1):19-23
pubmed: 17046160
Curr Biol. 2012 Sep 25;22(18):R794-5
pubmed: 23017990
Dev Cogn Neurosci. 2017 Apr;24:1-11
pubmed: 28088647
Hum Brain Mapp. 2014 Feb;35(2):593-615
pubmed: 23125108
Front Syst Neurosci. 2014 May 20;8:92
pubmed: 24904314
J Physiol. 1983 Jun;339:379-94
pubmed: 6887028
Neuroimage. 2005 Jan 15;24(2):332-8
pubmed: 15627576
Magn Reson Med. 2003 Jan;49(1):193-7
pubmed: 12509838
Arch Neurol. 1985 Jul;42(7):697-8
pubmed: 4015467
Hum Brain Mapp. 2001 Jun;13(2):55-73
pubmed: 11346886
Neuroimage. 2005 Jan 15;24(2):462-72
pubmed: 15627588
Sci Rep. 2016 Feb 05;6:20170
pubmed: 26846561
J Neurosci. 2006 Nov 15;26(46):12067-80
pubmed: 17108180
J Neurosci. 2017 Jun 28;37(26):6231-6241
pubmed: 28546307
Exp Brain Res. 1968;6(3):171-94
pubmed: 5712699
J Comp Neurol. 1997 Dec 15;389(2):249-63
pubmed: 9416920
Neuron. 2018 Nov 21;100(4):977-993.e7
pubmed: 30473014
Hum Brain Mapp. 2012 Nov;33(11):2741-9
pubmed: 21938757
Cerebellum. 2012 Jun;11(2):352-65
pubmed: 21373864
Brain Res. 2010 Jan 11;1307:63-71
pubmed: 19852951
Exp Brain Res. 1997 Dec;117(3):389-98
pubmed: 9438706
Trends Cogn Sci. 2000 Nov 1;4(11):417-423
pubmed: 11058819
Neuroimage. 2012 Jan 16;59(2):1560-70
pubmed: 21907811
Brain. 1998 Apr;121 ( Pt 4):561-79
pubmed: 9577385
Neuroscience. 2006 Apr 28;139(1):39-50
pubmed: 16325344
J Neurophysiol. 2010 Jun;103(6):3330-6
pubmed: 20393055
Cereb Cortex. 2016 Sep;26(9):3802-13
pubmed: 26286918
Q J Exp Psychol A. 2002 Oct;55(4):1339-62
pubmed: 12420998
J Cereb Blood Flow Metab. 1992 Nov;12(6):900-18
pubmed: 1400644
Trends Cogn Sci. 2017 May;21(5):313-332
pubmed: 28385461
J Cogn Neurosci. 2009 Apr;21(4):654-68
pubmed: 18702580
Neuroreport. 1999 Nov 26;10(17):3653-8
pubmed: 10619661
Neuroimage. 2013 Oct 15;80:62-79
pubmed: 23684880
Magn Reson Imaging. 2013 May;31(4):550-4
pubmed: 23228312
Front Hum Neurosci. 2013 Oct 04;7:623
pubmed: 24109446
Neuroimage. 2009 May 15;46(1):39-46
pubmed: 19457380
Neuropsychologia. 2003;41(8):989-94
pubmed: 12667534
Science. 1996 Apr 26;272(5261):545-7
pubmed: 8614803
J Neurosurg Pediatr. 2013 Dec;12(6):604-14
pubmed: 24073751
Cerebellum. 2002 Jul;1(3):165-84
pubmed: 12879979
Neuroimage. 2009 Jan 15;44(2):489-501
pubmed: 18835452
J Neurophysiol. 2011 Nov;106(5):2322-45
pubmed: 21795627
Cerebellum. 2008;7(4):589-94
pubmed: 19002543
JAMA. 2013 Nov 27;310(20):2191-4
pubmed: 24141714
J Physiol. 2000 Jan 15;522 Pt 2:297-309
pubmed: 10639105
Hum Brain Mapp. 2019 Nov 1;40(16):4732-4747
pubmed: 31361075
Soc Cogn Affect Neurosci. 2007 Sep;2(3):251-7
pubmed: 18985145
Med Image Comput Comput Assist Interv. 2006;9(Pt 2):58-66
pubmed: 17354756
Neuroimage. 2001 Dec;14(6):1370-86
pubmed: 11707093
Exp Brain Res. 1979 Jul 2;36(2):201-17
pubmed: 488196
Neuroimage. 2009 Oct 1;47(4):2073-82
pubmed: 19524048
Neuroimage. 2013 Oct 15;80:169-89
pubmed: 23684877
Cortex. 2007 Feb;43(2):219-32
pubmed: 17405668
Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7900-5
pubmed: 27357684
J Neurosurg Pediatr. 2010 Apr;5(4):329-34
pubmed: 20367335
J Cereb Blood Flow Metab. 1992 Jul;12(4):554-61
pubmed: 1618934
Neuroimage. 2002 Oct;17(2):825-41
pubmed: 12377157
Eur J Neurosci. 1992;4(4):289-295
pubmed: 12106355
Neuroimage. 2012 Aug 15;62(2):816-47
pubmed: 22584224
Cereb Cortex. 2010 Apr;20(4):953-65
pubmed: 19684249
MAGMA. 2015 Oct;28(5):485-92
pubmed: 25894812
Neuroimage. 2007 Jun;36(2):378-87
pubmed: 17459731
Neuroimage. 2012 Jan 2;59(1):83-93
pubmed: 21651986
J Cogn Neurosci. 1989 Spring;1(2):153-70
pubmed: 23968463
Neuropsychologia. 1971 Mar;9(1):97-113
pubmed: 5146491
Neuroimage. 2006 Feb 1;29(3):923-9
pubmed: 16253525
Hum Brain Mapp. 2005 Mar;24(3):165-72
pubmed: 15486988
Behav Neurosci. 1986 Aug;100(4):443-54
pubmed: 3741598
Science. 1966 Aug 5;153(3736):652-4
pubmed: 5939936
J Commun Disord. 2003 May-Jun;36(3):189-208
pubmed: 12742667
Trends Cogn Sci. 2018 Jun;22(6):517-530
pubmed: 29609894
Memory. 2010 May;18(4):394-412
pubmed: 20408039
Neuroimage. 2005 Apr 15;25(3):653-60
pubmed: 15808966
J Neurophysiol. 1999 Jul;82(1):484-8
pubmed: 10400975
Neuropsychologia. 2005;43(9):1227-37
pubmed: 15949507
Neuroimage. 2008 Jan 15;39(2):680-92
pubmed: 17950627
J Neurophysiol. 1967 Jul;30(4):675-96
pubmed: 6035687
Brain Res Cogn Brain Res. 2004 Apr;19(2):174-84
pubmed: 15019713
Annu Rev Neurosci. 2009;32:413-34
pubmed: 19555291
J Neurosci. 2001 May 15;21(10):3549-63
pubmed: 11331384
Neuroimage. 2018 May 15;172:437-449
pubmed: 29408539
Arch Clin Neuropsychol. 2009 Nov;24(7):711-7
pubmed: 19767297
Brain Struct Funct. 2019 Jan;224(1):485-499
pubmed: 30390152
J Neurophysiol. 2010 Oct;104(4):2257-65
pubmed: 20668275
Proc Natl Acad Sci U S A. 1985 Nov;82(21):7462-6
pubmed: 3877309
Cerebellum. 2014 Feb;13(1):151-77
pubmed: 23996631