Blood-brain barrier opening with focused ultrasound in experimental models of Parkinson's disease.
Parkinson's disease
alpha-synuclein
blood-brain barrier
focused ultrasound
therapy
Journal
Movement disorders : official journal of the Movement Disorder Society
ISSN: 1531-8257
Titre abrégé: Mov Disord
Pays: United States
ID NLM: 8610688
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
16
05
2019
revised:
28
06
2019
accepted:
01
07
2019
pubmed:
31
7
2019
medline:
27
6
2020
entrez:
31
7
2019
Statut:
ppublish
Résumé
Parkinson's disease has many symptomatic treatments, but there is no neuroprotective therapy currently available. The evolution of this disease is inexorably progressive, and halting or stopping the neurodegenerative process is a major unmet need. Parkinson's disease motor features at onset are typically limited to 1 body segment, that is, focal signs, and the nigrostriatal degeneration is highly asymmetrical and mainly present in the caudal putamen. Thus, clinically and neurobiologically the process is fairly limited early in its evolution. Tentatively, this would allow the possibility of intervening to halt neurodegeneration at the most vulnerable site. The recent use of new technologies such as focused ultrasound provides interesting prospects. In particular, the possibility of transiently opening the blood-brain barrier to facilitate penetrance of putative neuroprotective agents is a highly attractive approach that could be readily applied to Parkinson's disease. However, because there are currently effective treatments available (ie, dopaminergic pharmacological therapy), more experimental evidence is needed to construct a feasible and practical therapeutic approach to be tested early in the evolution of Parkinson's disease patients. In this review, we provide the current evidence for the application of blood-brain barrier opening in experimental models of Parkinson's disease and discuss its potential clinical applicability. © 2019 International Parkinson and Movement Disorder Society.
Identifiants
pubmed: 31361356
doi: 10.1002/mds.27804
pmc: PMC7213581
mid: NIHMS1049883
doi:
Substances chimiques
Antiparkinson Agents
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1252-1261Subventions
Organisme : NIA NIH HHS
ID : R01 AG038961
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB009041
Pays : United States
Informations de copyright
© 2019 International Parkinson and Movement Disorder Society.
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