Binocular facilitation in light-mediated melatonin suppression?
binocular integration
binocular summation
light
melanospin
melatonin suppression
non-image forming function
Journal
Journal of pineal research
ISSN: 1600-079X
Titre abrégé: J Pineal Res
Pays: England
ID NLM: 8504412
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
received:
30
05
2019
revised:
25
07
2019
accepted:
25
07
2019
pubmed:
31
7
2019
medline:
13
3
2020
entrez:
31
7
2019
Statut:
ppublish
Résumé
In humans, the production of melatonin is suppressed by light exposure. This effect is mediated by a retinal pathway involving the melanopsin-containing intrinsincally photosensitive retinal ganglion cells (ipRGCs), which exhibit maximum sensitivity to short-wavelength light. Here, based on extant and published data, we examine how signals from the two eyes are integrated in driving the suppression of melatonin by light. We find that melatonin suppression by light exposure to two eyes corresponds to a sensitivity shift by about 1.2 log units (factor ~17.4).
Substances chimiques
Rod Opsins
0
melanopsin
0
Melatonin
JL5DK93RCL
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12602Subventions
Organisme : Wellcome Trust
ID : 204686/Z/16/Z
Pays : United Kingdom
Informations de copyright
© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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