Metabolic flexibility in melanoma: A potential therapeutic target.
Cutaneous melanoma
Glycolysis
Metabolic alterations
OXPHOS
Therapeutic strategies
Journal
Seminars in cancer biology
ISSN: 1096-3650
Titre abrégé: Semin Cancer Biol
Pays: England
ID NLM: 9010218
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
30
03
2019
revised:
11
07
2019
accepted:
23
07
2019
pubmed:
31
7
2019
medline:
6
5
2020
entrez:
31
7
2019
Statut:
ppublish
Résumé
Cutaneous melanoma (CM) represents one of the most metastasizing and drug resistant solid tumors. CM is characterized by a remarkable metabolic plasticity and an important connection between oncogenic activation and energetic metabolism. In fact, melanoma cells can use both cytosolic and mitochondrial compartments to produce adenosine triphosphate (ATP) during cancer progression. However, the CM energetic demand mainly depends on glycolysis, whose upregulation is strictly linked to constitutive activation of BRAF/MAPK pathway affected by BRAF
Identifiants
pubmed: 31362075
pii: S1044-579X(19)30004-5
doi: 10.1016/j.semcancer.2019.07.016
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
187-207Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.