Multi-study validation of data-driven disease progression models to characterize evolution of biomarkers in Alzheimer's disease.

Aged Aged, 80 and over Alzheimer Disease / cerebrospinal fluid Amyloid beta-Peptides / cerebrospinal fluid Biomarkers / cerebrospinal fluid Cohort Studies Cross-Sectional Studies Databases, Factual / standards Disease Progression Female Humans Male Models, Theoretical Neuropsychological Tests / standards tau Proteins / cerebrospinal fluid
Alzheimer's disease Biomarkers progression Event-based models Inter-cohort validation Patient staging

Journal

NeuroImage. Clinical
ISSN: 2213-1582
Titre abrégé: Neuroimage Clin
Pays: Netherlands
ID NLM: 101597070

Informations de publication

Date de publication:
2019
Historique:
received: 18 01 2019
revised: 24 06 2019
accepted: 19 07 2019
pubmed: 31 7 2019
medline: 17 9 2020
entrez: 31 7 2019
Statut: ppublish

Résumé

Understanding the sequence of biological and clinical events along the course of Alzheimer's disease provides insights into dementia pathophysiology and can help participant selection in clinical trials. Our objective is to train two data-driven computational models for sequencing these events, the Event Based Model (EBM) and discriminative-EBM (DEBM), on the basis of well-characterized research data, then validate the trained models on subjects from clinical cohorts characterized by less-structured data-acquisition protocols. Seven independent data cohorts were considered totalling 2389 cognitively normal (CN), 1424 mild cognitive impairment (MCI) and 743 Alzheimer's disease (AD) patients. The Alzheimer's Disease Neuroimaging Initiative (ADNI) data set was used as training set for the constriction of disease models while a collection of multi-centric data cohorts was used as test set for validation. Cross-sectional information related to clinical, cognitive, imaging and cerebrospinal fluid (CSF) biomarkers was used. Event sequences obtained with EBM and DEBM showed differences in the ordering of single biomarkers but according to both the first biomarkers to become abnormal were those related to CSF, followed by cognitive scores, while structural imaging showed significant volumetric decreases at later stages of the disease progression. Staging of test set subjects based on sequences obtained with both models showed good linear correlation with the Mini Mental State Examination score (R

Identifiants

DOI: 10.1016/j.nicl.2019.101954 PMID: 31362149 PMC: PMC6675943
pubmed: 31362149
pii: S2213-1582(19)30304-3
doi: 10.1016/j.nicl.2019.101954
pmc: PMC6675943
pii:
doi:

Substances chimiques

Amyloid beta-Peptides 0
Biomarkers 0
MAPT protein, human 0
tau Proteins 0

Types de publication

Journal Article Multicenter Study Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Validation Study

Langues

eng

Sous-ensembles de citation

IM

Pagination

101954

Subventions

Organisme : NCRR NIH HHS
ID : U24 RR021382
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH056584
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG024904
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG026276
Pays : United States
Organisme : Medical Research Council
ID : MR/T027800/1
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : R01 AG021910
Pays : United States
Organisme : NIMH NIH HHS
ID : P50 MH071616
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG003991
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG005681
Pays : United States

Informations de copyright

Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

Références

Neuroimage. 2012 Apr 15;60(3):1880-9
pubmed: 22281676
Neurology. 2009 Nov 24;73(21):1738-45
pubmed: 19933974
Neuroimage. 2017 Jan;144(Pt B):305-308
pubmed: 27046114
Am J Psychiatry. 1984 Nov;141(11):1356-64
pubmed: 6496779
Psychiatry Res. 2014 Nov 30;224(2):81-8
pubmed: 25194437
Curr Opin Neurol. 2017 Aug;30(4):371-379
pubmed: 28520598
Eur Neurol. 1993;33(6):403-8
pubmed: 8307060
J Alzheimers Dis. 2014;41(1):313-27
pubmed: 24614907
Brain. 2018 May 1;141(5):1529-1544
pubmed: 29579160
Brain Imaging Behav. 2016 Sep;10(3):901-10
pubmed: 26572143
Methods. 2012 Apr;56(4):484-93
pubmed: 22503777
Lancet Neurol. 2003 Oct;2(10):605-13
pubmed: 14505582
Nat Rev Neurol. 2011 Jul 05;7(8):429-38
pubmed: 21727938
J Clin Exp Neuropsychol. 2007 Jul;29(5):561-7
pubmed: 17564921
Acta Neuropathol. 1991;82(4):239-59
pubmed: 1759558
Neuroimage. 2019 Apr 15;190:56-68
pubmed: 29079521
Am J Geriatr Psychiatry. 2006 Feb;14(2):139-44
pubmed: 16473978
Nat Commun. 2016 Jun 21;7:11934
pubmed: 27327500
Curr Alzheimer Res. 2012 Jul;9(6):628-45
pubmed: 22471860
Alzheimers Dement. 2011 May;7(3):270-9
pubmed: 21514249
Nat Rev Neurol. 2010 Mar;6(3):131-44
pubmed: 20157306
Nat Rev Neurol. 2010 Feb;6(2):67-77
pubmed: 20139996
Med Image Comput Comput Assist Interv. 2014;17(Pt 3):305-12
pubmed: 25320813
J Immunoassay. 2000 May-Aug;21(2-3):165-209
pubmed: 10929886
Funct Neurol. 2013 Jul-Sep;28(3):175-90
pubmed: 24139654
Alzheimers Res Ther. 2018 Oct 30;10(1):112
pubmed: 30376881
Inf Process Med Imaging. 2015;24:711-22
pubmed: 26223048
Curr Alzheimer Res. 2013 May 1;10(4):357-64
pubmed: 23061918
J Neural Transm Suppl. 2002;(62):105-16
pubmed: 12456056
Lancet Neurol. 2013 Feb;12(2):207-16
pubmed: 23332364
Brain. 2009 May;132(Pt 5):1310-23
pubmed: 19042931
Curr Alzheimer Res. 2012 Jul;9(6):646-63
pubmed: 22471867
Brain. 2018 Jun 1;141(6):1665-1677
pubmed: 29741648
PLoS One. 2015 Mar 17;10(3):e0117692
pubmed: 25781983
Alzheimer Dis Assoc Disord. 2007 Jul-Sep;21(3):249-58
pubmed: 17804958
Alzheimers Dement. 2009 Jul;5(4):307-17
pubmed: 19560101
Lancet Neurol. 2014 Jun;13(6):614-29
pubmed: 24849862
Alzheimers Res Ther. 2010 Aug 31;2(4):23
pubmed: 20807454
JAMA Neurol. 2014 Apr;71(4):505-8
pubmed: 24493463
Brain. 2014 Sep;137(Pt 9):2564-77
pubmed: 25012224
Nat Commun. 2018 Oct 15;9(1):4273
pubmed: 30323170
Neuroimage. 2012 Nov 15;63(3):1478-86
pubmed: 22885136
Lancet Neurol. 2010 Jan;9(1):119-28
pubmed: 20083042
J Am Geriatr Soc. 1992 Sep;40(9):922-35
pubmed: 1512391
Proc Natl Acad Sci U S A. 1991 Apr 1;88(7):2845-9
pubmed: 2011592
Neuroimage. 2019 Feb 1;186:518-532
pubmed: 30471388
Arch Neurol. 2002 Nov;59(11):1737-46
pubmed: 12433261
Alzheimers Res Ther. 2018 Sep 27;10(1):100
pubmed: 30261928
Alzheimers Dement. 2010 May;6(3):239-46
pubmed: 20451872
Ann Clin Transl Neurol. 2018 Apr 02;5(5):570-582
pubmed: 29761120
Alzheimers Dement. 2014 Oct;10(5 Suppl):S400-10
pubmed: 24656849
Int J Geriatr Psychiatry. 2003 Nov;18(11):1021-8
pubmed: 14618554
J Intern Med. 2016 Jun;279(6):576-91
pubmed: 26940242
Biometrics. 1988 Sep;44(3):837-45
pubmed: 3203132
J Cogn Neurosci. 2007 Sep;19(9):1498-507
pubmed: 17714011
Neurology. 2016 Aug 2;87(5):539-47
pubmed: 27371494
Alzheimers Res Ther. 2017 Sep 12;9(1):73
pubmed: 28899429
Front Neurol. 2018 May 04;9:235
pubmed: 29780348
Alzheimers Dement. 2011 May;7(3):280-92
pubmed: 21514248

Auteurs

Damiano Archetti (D)

IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy. Electronic address: darchetti@fatebenefratelli.eu.

Silvia Ingala (S)

Department of Radiology and Nuclear Medicine, Amsterdam UMC Location VUmc, Amsterdam, The Netherlands. Electronic address: s.ingala@vumc.nl.

Vikram Venkatraghavan (V)

Biomedical Imaging Group Rotterdam, Depts. of Medical Informatics & Radiology, Erasmus MC, The Netherlands. Electronic address: v.venkatraghavan@erasmusmc.nl.

Viktor Wottschel (V)

Department of Radiology and Nuclear Medicine, Amsterdam UMC Location VUmc, Amsterdam, The Netherlands. Electronic address: v.wottschel@vumc.nl.

Alexandra L Young (AL)

Centre for Medical Image Computing, Department of Computer Science, UCL, London, UK. Electronic address: alexandra.young.11@ucl.ac.uk.

Maura Bellio (M)

Centre for Medical Image Computing, Department of Computer Science, UCL, London, UK. Electronic address: maura.bellio.16@ucl.ac.uk.

Esther E Bron (EE)

Biomedical Imaging Group Rotterdam, Depts. of Medical Informatics & Radiology, Erasmus MC, The Netherlands. Electronic address: e.bron@erasmusmc.nl.

Stefan Klein (S)

Biomedical Imaging Group Rotterdam, Depts. of Medical Informatics & Radiology, Erasmus MC, The Netherlands. Electronic address: s.klein@erasmusmc.nl.

Frederik Barkhof (F)

Department of Radiology and Nuclear Medicine, Amsterdam UMC Location VUmc, Amsterdam, The Netherlands; Institutes of Neurology and Healthcare Engineering, UCL, London, UK. Electronic address: f.barkhof@vumc.nl.

Daniel C Alexander (DC)

Centre for Medical Image Computing, Department of Computer Science, UCL, London, UK. Electronic address: d.alexander@ucl.ac.uk.

Neil P Oxtoby (NP)

Centre for Medical Image Computing, Department of Computer Science, UCL, London, UK. Electronic address: n.oxtoby@ucl.ac.uk.

Giovanni B Frisoni (GB)

University of Geneva, Geneva, Switzerland; IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy. Electronic address: giovanni.frisoni@unige.ch.

Alberto Redolfi (A)

IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy. Electronic address: aredolfi@fatebenefratelli.eu.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Multi-study validation of data-driven disease...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › Multi-study validation of data-driven disease...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Multi-study validation of data-driven disease...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Peptides bêta-amyloïdes › Multi-study validation of data-driven disease...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Multi-study validation of data-driven disease...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Multi-study validation of data-driven disease...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études transversales › Multi-study validation of data-driven disease...
questionsmedicales.fr › Sciences de l'information › Mémorisation et recherche des informations › Bases de données comme sujet › Bases de données factuelles › Multi-study validation of data-driven disease...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › Multi-study validation of data-driven disease...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Multi-study validation of data-driven disease...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Multi-study validation of data-driven disease...
questionsmedicales.fr › Disciplines et activités comportementales › Tests psychologiques › Tests neuropsychologiques › Multi-study validation of data-driven disease...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Protéines associées aux microtubules › Protéines tau › Multi-study validation of data-driven disease...