Nanoparticle Vaccines for Inducing HIV-1 Neutralizing Antibodies.
HIV-1 Env
liposomes
self-assembling protein nanoparticles
virus-like particles
Journal
Vaccines
ISSN: 2076-393X
Titre abrégé: Vaccines (Basel)
Pays: Switzerland
ID NLM: 101629355
Informations de publication
Date de publication:
29 Jul 2019
29 Jul 2019
Historique:
received:
01
07
2019
revised:
23
07
2019
accepted:
25
07
2019
entrez:
1
8
2019
pubmed:
1
8
2019
medline:
1
8
2019
Statut:
epublish
Résumé
The enormous sequence diversity between human immunodeficiency virus type 1 (HIV-1) strains poses a major roadblock for generating a broadly protective vaccine. Many experimental HIV-1 vaccine efforts are therefore aimed at eliciting broadly neutralizing antibodies (bNAbs) that are capable of neutralizing the majority of circulating HIV-1 strains. The envelope glycoprotein (Env) trimer on the viral membrane is the sole target of bNAbs and the key component of vaccination approaches aimed at eliciting bNAbs. Multimeric presentation of Env on nanoparticles often plays a critical role in these strategies. Here, we will discuss the different aspects of nanoparticles in Env vaccination, including recent insights in immunological processes underlying their perceived advantages, the different nanoparticle platforms and the various immunogenicity studies that employed nanoparticles to improve (neutralizing) antibody responses against Env.
Identifiants
pubmed: 31362378
pii: vaccines7030076
doi: 10.3390/vaccines7030076
pmc: PMC6789800
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Bill and Melinda Gates Foundation
ID : OPP1111923 and OPP1132237
Organisme : Horizon 2020
ID : 681137
Organisme : Foundation for the National Institutes of Health
ID : PO1 AI110657
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