Tadalafil 5 mg Alone or in Combination with Tamsulosin 0.4 mg for the Management of Men with Lower Urinary Tract Symptoms and Erectile Dysfunction: Results of a Prospective Observational Trial.

benign prostatic hyperplasia erectile dysfunction lower urinary tract symptoms medical therapy tadalafil tamsulosin

Journal

Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588

Informations de publication

Date de publication:
29 Jul 2019
Historique:
received: 25 06 2019
revised: 17 07 2019
accepted: 25 07 2019
entrez: 1 8 2019
pubmed: 1 8 2019
medline: 1 8 2019
Statut: epublish

Résumé

Tadalafil 5 mg represents the standard for men with Erectile dysfunction (ED) and lower urinary tract symptoms (LUTS)/benign prostatic enlargement (BPE). We carried out an observational trial aiming to assess the efficacy and safety of Tadalafil compared with Tadalafil plus Tamsulosin. Seventy-five patients complaining of ED and LUTS were treated for 12-weeks with Tadalafil plus placebo (TAD+PLA-group) or with combination therapy tadalafil plus tamsulosin (TAD+TAM-group). Efficacy variables were: International Index of Erectile Function (IIEF), International Prostate Symptom Score (IPSS), maximum urinary flow rate (Qmax) and safety assessments. Data were evaluated using paired samples

Identifiants

pubmed: 31362410
pii: jcm8081126
doi: 10.3390/jcm8081126
pmc: PMC6723816
pii:
doi:

Types de publication

Journal Article

Langues

eng

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Auteurs

Arcangelo Sebastianelli (A)

Department of Minimally Invasive and Robotic Urologic Surgery and Kidney Transplantation, University of Florence, 50134 Florence, Italy. arcangelo.sebastianelli@gmail.com.

Pietro Spatafora (P)

Department of Minimally Invasive and Robotic Urologic Surgery and Kidney Transplantation, University of Florence, 50134 Florence, Italy.

Jacopo Frizzi (J)

Department of Minimally Invasive and Robotic Urologic Surgery and Kidney Transplantation, University of Florence, 50134 Florence, Italy.

Omar Saleh (O)

Department of Minimally Invasive and Robotic Urologic Surgery and Kidney Transplantation, University of Florence, 50134 Florence, Italy.

Maurizio Sessa (M)

Department of Experimental Medicine, Section of Pharmacology "L. Donatelli", University of Campania "L. Vanvitelli", 80138 Naples, Italy.

Cosimo De Nunzio (C)

Department of Urology, Sant'Andrea Hospital, University "La Sapienza", 00189 Rome, Italy.

Andrea Tubaro (A)

Department of Urology, Sant'Andrea Hospital, University "La Sapienza", 00189 Rome, Italy.

Linda Vignozzi (L)

Department of Clinical Physiopathology, University of Florence, 50134 Florence, Italy.

Mario Maggi (M)

Department of Clinical Physiopathology, University of Florence, 50134 Florence, Italy.

Sergio Serni (S)

Department of Minimally Invasive and Robotic Urologic Surgery and Kidney Transplantation, University of Florence, 50134 Florence, Italy.

Kevin T McVary (KT)

Division of Urology, Southern Illinois University School of Medicine, Springfield, IL 62702, USA.

Steven A Kaplan (SA)

Department of Urology, Icahn School of Medicine at Mount Sinai, New York City, New York, NY 10029, USA.

Stavros Gravas (S)

Department of Urology, University of Thessaly, Larissa 41222, Greece.

Christopher Chapple (C)

Department of Urology, Sheffield Teaching Hospitals NHS Trust, Sheffield S102JF, UK.

Mauro Gacci (M)

Department of Minimally Invasive and Robotic Urologic Surgery and Kidney Transplantation, University of Florence, 50134 Florence, Italy.

Classifications MeSH