Phase Angle: A Possible Biomarker to Quantify Inflammation in Subjects with Obesity and 25(OH)D Deficiency.
Adiposity
Adolescent
Adult
Biomarkers
/ blood
Body Composition
Body Mass Index
Cross-Sectional Studies
Electric Impedance
Female
Humans
Inflammation
/ blood
Male
Middle Aged
Obesity
/ blood
Predictive Value of Tests
Reproducibility of Results
Vitamin D
/ analogs & derivatives
Vitamin D Deficiency
/ blood
Young Adult
Bioelectrical Impedance Analysis (BIA)
Inflammation.
Obesity
Phase Angle (PhA)
Vitamin D
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
29 07 2019
29 07 2019
Historique:
received:
19
06
2019
revised:
11
07
2019
accepted:
24
07
2019
entrez:
1
8
2019
pubmed:
1
8
2019
medline:
21
1
2020
Statut:
epublish
Résumé
Obesity is associated to chronic low-grade metabolic inflammation and hypovitaminosis D. Among extra-skeletal effects, an important role in inflammation has been described for vitamin D (25(OH)D). Phase angle (PhA) is a bioelectrical impedance analysis (BIA) parameter that represents an indicator of cellular health in chronic inflammatory states. However, it is still unknown whether a low 25(OH)D levels might correlate with PhA in obesity. Considering the lack of evidence correlating the 25(OH)D levels with PhA in obesity, the aim of this study was to investigate their possible relationship in a group of patients with obesity stratified according to body mass index (BMI) categories. Four hundred and fifty-five adult subjects (219 males and 236 females; 36 ± 11 years) were enrolled. Body composition, including PhA, was assessed using a BIA phase-sensitive system. Serum levels of 25(OH)D was determined by a direct competitive chemiluminescence immunoassay. Most of the participants were affected by grade III obesity (24%) and had 25(OH)D deficiency (67%). Subjects with 25(OH)D deficiency had highest BMI (
Identifiants
pubmed: 31362440
pii: nu11081747
doi: 10.3390/nu11081747
pmc: PMC6723101
pii:
doi:
Substances chimiques
Biomarkers
0
Vitamin D
1406-16-2
25-hydroxyvitamin D
A288AR3C9H
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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