Mechanical stress-induced cell death in breast cancer cells.
Apoptosis
Breast cancer cells
Mechanical stress-induced cell death (MSICD)
Necrosis
Oscillating compression stress
Journal
Biology open
ISSN: 2046-6390
Titre abrégé: Biol Open
Pays: England
ID NLM: 101578018
Informations de publication
Date de publication:
16 Aug 2019
16 Aug 2019
Historique:
pubmed:
1
8
2019
medline:
1
8
2019
entrez:
1
8
2019
Statut:
epublish
Résumé
Providing an external mechanical stress to cancer cells seems to be an effective approach to treat cancer locally. Numbers of reports on cancer cell death subjected to mechanical stress loading are increasing, but they are more focused on apoptosis. Inducing necrosis is also important in attracting more immune cells to the cancer site via the release of danger-associated molecular patterns from cancer cells. Here we applied dynamic compression to breast cancer cells with a low frequency (0.1-30 Hz) and for a short duration (30-300 s) and they resulted in a mixed mode of apoptosis and necrosis dominant with necrotic cell death, which we call mechanical stress-induced cell death (MSICD). The necrotic cell damage of mechanically treated breast cancer cells increased in a force-dependent and time-dependent manner while a trend of frequency-independent MSICD was observed.
Identifiants
pubmed: 31362953
pii: bio.043133
doi: 10.1242/bio.043133
pmc: PMC6737978
pii:
doi:
Types de publication
Journal Article
Langues
eng
Informations de copyright
© 2019. Published by The Company of Biologists Ltd.
Déclaration de conflit d'intérêts
Competing interestsThe authors declare no competing or financial interests.
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