Molecular epidemiology of JC polyomavirus in HIV-infected patients and healthy individuals from Iran.
Adolescent
Adult
Age Factors
Capsid Proteins
/ genetics
Child
Child, Preschool
DNA, Viral
/ urine
Female
Genotype
HIV Infections
/ complications
Healthy Volunteers
Humans
Immunocompromised Host
Infant
Infant, Newborn
Iran
/ epidemiology
JC Virus
/ genetics
Male
Middle Aged
Polyomavirus Infections
/ epidemiology
Tumor Virus Infections
/ epidemiology
Virus Shedding
Young Adult
Genotype
JC polyomavirus
Polymerase chain reaction
Polyomavirus
VP1 gene
Journal
Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]
ISSN: 1678-4405
Titre abrégé: Braz J Microbiol
Pays: Brazil
ID NLM: 101095924
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
06
04
2019
accepted:
02
07
2019
pubmed:
1
8
2019
medline:
11
11
2020
entrez:
1
8
2019
Statut:
ppublish
Résumé
JC polyomavirus (JCPyV) is the causative agent for progressive multifocal leukoencephalopathy (PML) in immunocompromised patients. More than 40% of healthy population excretes JCPyV particles in their urine. As JCPyV is ubiquitous in human, the definition of genotype distribution can help trace population migration. In this study, to define the frequency of JCPyV in southwest of Iran, urine samples of 161 volunteers including 80 healthy individuals and 81 HIV-infected patients were collected. PCR assays and sequence analysis were performed using JCPyV-specific primers designed against VP1 coding region. JCPyV DNA was detected in 65 out of 81 urine samples (80.2%) of HIV-infected, and in 43 out of 80 urine samples (53.8%) of healthy individuals (P = 0.001). The shedding of JCPyV among HIV-infected patients revealed an age-related pattern while such relationship was not observed in healthy individuals group. The most common genotype found in this region was genotype 3A (80.8%), followed by genotype 2D (11.5%), 4 (3.8%), and 7 (3.8%). The frequency of JCPyV in the urine of HIV-infected patients was found significantly higher than in the healthy individuals (P = 0.001).
Identifiants
pubmed: 31364012
doi: 10.1007/s42770-019-00117-y
pii: 10.1007/s42770-019-00117-y
pmc: PMC7058753
doi:
Substances chimiques
Capsid Proteins
0
DNA, Viral
0
VP1 protein, polyomavirus
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
37-43Subventions
Organisme : Ahvaz Jundishapur University of Medical Sciences
ID : B-97042
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