Glucagon-like peptide-2 mobilizes lipids from the intestine by a systemic nitric oxide-independent mechanism.
Celiac Artery
/ diagnostic imaging
Chylomicrons
/ chemistry
Glucagon-Like Peptide 2
/ metabolism
Humans
Intestinal Mucosa
/ drug effects
Lipoproteins
/ blood
Male
Mesenteric Artery, Superior
/ diagnostic imaging
Middle Aged
Nitric Oxide
/ metabolism
Peptides
/ pharmacology
Single-Blind Method
Triglycerides
/ blood
Ultrasonography, Doppler
clinical physiology
dyslipidaemia
Journal
Diabetes, obesity & metabolism
ISSN: 1463-1326
Titre abrégé: Diabetes Obes Metab
Pays: England
ID NLM: 100883645
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
30
05
2019
revised:
09
07
2019
accepted:
25
07
2019
pubmed:
1
8
2019
medline:
29
9
2020
entrez:
1
8
2019
Statut:
ppublish
Résumé
To test the hypothesis that gut hormone glucagon-like peptide-2 (GLP-2) mobilizes intestinal triglyceride (TG) stores and stimulates chylomicron secretion by a nitric oxide (NO)-dependent mechanism in humans. In a randomized, single-blind, cross-over study, 10 healthy male volunteers ingested a high-fat formula followed, 7 hours later, by one of three treatments: NO synthase inhibitor L-N Teduglutide rapidly increased mesenteric blood flow and TG concentrations in plasma, in TG-rich lipoproteins, and most robustly in chylomicrons. L-NMMA significantly attenuated teduglutide-induced enhancement of mesenteric blood flow but not TG mobilization and chylomicron secretion. GLP-2 mobilization of TG stores and stimulation of chylomicron secretion from the small intestine appears to be independent of systemic NO in humans.
Substances chimiques
Chylomicrons
0
Glucagon-Like Peptide 2
0
Lipoproteins
0
Peptides
0
Triglycerides
0
lipoprotein triglyceride
0
Nitric Oxide
31C4KY9ESH
teduglutide
7M19191IKG
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2535-2541Subventions
Organisme : CIHR
Pays : Canada
Informations de copyright
© 2019 John Wiley & Sons Ltd.
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