Protective effects of trans-2,3,5,4'-tetrahydroxystilbene 2-O-β-d-glucopyranoside on liver fibrosis and renal injury induced by CCl
Animals
Carbon Tetrachloride
/ adverse effects
Down-Regulation
/ drug effects
Drugs, Chinese Herbal
/ administration & dosage
Fallopia multiflora
/ chemistry
Female
Glucosides
/ administration & dosage
Humans
Kidney
/ drug effects
Kidney Diseases
/ drug therapy
Liver
/ metabolism
Liver Cirrhosis
/ drug therapy
MAP Kinase Signaling System
/ drug effects
Phosphorylation
/ drug effects
Rats
Rats, Sprague-Dawley
Signal Transduction
/ drug effects
Smad1 Protein
/ genetics
Smad2 Protein
/ genetics
Stilbenes
/ administration & dosage
Transforming Growth Factor beta
/ metabolism
Transforming Growth Factor beta1
/ metabolism
Journal
Food & function
ISSN: 2042-650X
Titre abrégé: Food Funct
Pays: England
ID NLM: 101549033
Informations de publication
Date de publication:
01 Aug 2019
01 Aug 2019
Historique:
pubmed:
1
8
2019
medline:
6
2
2020
entrez:
1
8
2019
Statut:
ppublish
Résumé
Both as a food and an herbal plant, Polygonum multiflorum (PM) has long been used in food and prescriptions for several centuries in Southeast Asia. trans-2,3,5,4'-tetrahydroxystilbene 2-O-β-d-glucopyranoside (trans-THSG) is one of the major compounds derived from PM and has been reported to exhibit multiple biological activities such as antioxidation and anti-obesity activities among others. The current study was aimed at investigating the effects of trans-THSG on liver fibrosis and renal injury in a carbon tetrachloride (CCl
Substances chimiques
2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside
0
Drugs, Chinese Herbal
0
Glucosides
0
Smad1 Protein
0
Smad2 Protein
0
Stilbenes
0
Transforming Growth Factor beta
0
Transforming Growth Factor beta1
0
Carbon Tetrachloride
CL2T97X0V0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM