Gain-of-function mutations in the UNC-2/CaV2α channel lead to excitation-dominant synaptic transmission in
C. elegans
GABA
acetylcholine
behavior
calcium
genetics
genomics
ion channel
neuroscience
neurotransmission
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
05 08 2019
05 08 2019
Historique:
received:
18
02
2019
accepted:
30
07
2019
pubmed:
1
8
2019
medline:
12
2
2020
entrez:
1
8
2019
Statut:
epublish
Résumé
Mutations in pre-synaptic voltage-gated calcium channels can lead to familial hemiplegic migraine type 1 (FHM1). While mammalian studies indicate that the migraine brain is hyperexcitable due to enhanced excitation or reduced inhibition, the molecular and cellular mechanisms underlying this excitatory/inhibitory (E/I) imbalance are poorly understood. We identified a gain-of-function (gf) mutation in the
Identifiants
pubmed: 31364988
doi: 10.7554/eLife.45905
pii: 45905
pmc: PMC6713474
doi:
pii:
Substances chimiques
Caenorhabditis elegans Proteins
0
Membrane Proteins
0
Mutant Proteins
0
unc-2 protein, C elegans
0
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIH HHS
ID : NS107475
Pays : United States
Organisme : NIH HHS
ID : P40 OD010440
Pays : United States
Organisme : NIH HHS
ID : NS082525
Pays : United States
Organisme : NINDS NIH HHS
ID : R56 NS064263
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS107475
Pays : United States
Organisme : NIH HHS
ID : GM084491
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS064263
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM084491
Pays : United States
Organisme : NIH HHS
ID : NS064263
Pays : United States
Informations de copyright
© 2019, Huang et al.
Déclaration de conflit d'intérêts
YH, JP, DR, SG, BM, JG, YS, MF, MZ, MA No competing interests declared
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