Biomarkers predictive value for early diagnosis of Stroke-Associated Pneumonia.
Journal
Annals of clinical and translational neurology
ISSN: 2328-9503
Titre abrégé: Ann Clin Transl Neurol
Pays: United States
ID NLM: 101623278
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
25
04
2019
revised:
24
06
2019
accepted:
25
06
2019
pubmed:
1
8
2019
medline:
13
5
2020
entrez:
1
8
2019
Statut:
ppublish
Résumé
To confirm the diagnostic accuracy of candidate biomarkers in stroke-associated pneumonia (SAP), we prospectively enrolled ischemic stroke patients with NIHSS ≥ 10 on admission from March-2016 to August-2017. Blood samples were collected at baseline, 24 and 48 h after stroke onset. Biomarkers (MR-proADM, suPAR, SAA) were determined by immunoassays. Regarding biomarkers, MR-proADM at 24 h (P = 0.04) and both suPAR and SAA at 48 h (P = 0.036 and P = 0.057) were associated with pneumonia. The combination of SAA > 25.15 mg/dL and suPAR> 3.14 ng/mL at 48 h had 80% sensitivity and 95.8% specificity when both biomarkers were above the cut-off. The evaluated biomarkers represent promising tools to be evaluated in future large, prospective studies on SAP. An accurate SAP diagnosis by thorax CT might help to reduce variability in such studies.
Identifiants
pubmed: 31365180
doi: 10.1002/acn3.50849
pmc: PMC6764629
doi:
Substances chimiques
Biomarkers
0
Peptide Fragments
0
Protein Precursors
0
Receptors, Urokinase Plasminogen Activator
0
Serum Amyloid A Protein
0
mid-regional pro-adrenomedullin, human
0
Adrenomedullin
148498-78-6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1882-1887Subventions
Organisme : ISCIII
ID : PI14/00971
Pays : International
Organisme : Improving Translational Research Potential at the Institute of Biomedicine of Seville
ID : REGPOT-2013-1
Pays : International
Organisme : Cooperative Cerebrovascular Disease Research Network (INVICTUS+)
ID : RD16/0019/0015
Pays : International
Organisme : Instituto de Salud Carlos III
ID : JR16/0008
Pays : International
Informations de copyright
© 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.
Références
Nat Rev Neurosci. 2005 Oct;6(10):775-86
pubmed: 16163382
N Engl J Med. 1999 Feb 11;340(6):448-54
pubmed: 9971870
J Stroke. 2019 May;21(2):217-219
pubmed: 30991796
Stroke. 2015 Aug;46(8):2335-40
pubmed: 26111886
Am J Infect Control. 2008 Jun;36(5):309-32
pubmed: 18538699
J Stroke Cerebrovasc Dis. 2018 Mar;27(3):673-676
pubmed: 29103860
PLoS One. 2012;7(10):e48309
pubmed: 23118979
Curr Opin Crit Care. 2007 Oct;13(5):578-85
pubmed: 17762239
Am J Crit Care. 2010 Jul;19(4):357-64
pubmed: 19875722
J Neuroimmunol. 2017 Nov 15;312:19-23
pubmed: 28886956
Dis Markers. 2009;27(3):157-72
pubmed: 19893210
Clin Proteomics. 2017 Jul 12;14:27
pubmed: 28701906