Galectin 3: an extraordinary multifunctional protein in dermatology. Current knowledge and perspectives.
Journal
Anais brasileiros de dermatologia
ISSN: 1806-4841
Titre abrégé: An Bras Dermatol
Pays: Spain
ID NLM: 0067662
Informations de publication
Date de publication:
29 07 2019
29 07 2019
Historique:
received:
08
05
2018
accepted:
14
01
2019
entrez:
1
8
2019
pubmed:
1
8
2019
medline:
4
9
2019
Statut:
epublish
Résumé
Galectin 3 is a unique ~31 kDa protein that recognizes the N-acetyl-lactosamine structure of several glycoconjugates. It mainly occurs in epithelial and myeloid cells, but is also found in a variety of human cell types. In view of the crucial role played by galectin 3 in the regulation of cellular processes of essential importance and in the pathogenetic mechanisms of diverse disorders, it is not surprising that, particularly in the last three decades, the attention of the scientific community has been increasingly drawn to this extraordinary and multifunctional galectin. In this paper the authors summarize current knowledge on the expression of galectin 3 in normal and diseased human skin, its implications in the pathogenesis, diagnosis and prognosis of cutaneous disorders, and the perspectives of a novel approach to the treatment of the latter using galectin 3 or its inhibitors/antagonists.
Identifiants
pubmed: 31365668
pii: S0365-0596(20)30618-8
doi: 10.1590/abd1806-4841.20198426
pmc: PMC6668939
pii:
doi:
Substances chimiques
Amino Sugars
0
Blood Proteins
0
Galectin 3
0
Galectins
0
LGALS3 protein, human
0
N-acetyllactosamine
3Y5B2K5OOK
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
348-354Références
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