Integrated Analysis of TP53 Gene and Pathway Alterations in The Cancer Genome Atlas.
PanCanAtlas
TCGA
TP53
TP53 mutation
The Cancer Genome Atlas
chromosomal instability
p53
p53 signaling pathway
p53 signature
p53 targets
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
30 07 2019
30 07 2019
Historique:
received:
29
11
2018
revised:
09
05
2019
accepted:
27
06
2019
entrez:
1
8
2019
pubmed:
1
8
2019
medline:
20
8
2020
Statut:
ppublish
Résumé
The TP53 tumor suppressor gene is frequently mutated in human cancers. An analysis of five data platforms in 10,225 patient samples from 32 cancers reported by The Cancer Genome Atlas (TCGA) enables comprehensive assessment of p53 pathway involvement in these cancers. More than 91% of TP53-mutant cancers exhibit second allele loss by mutation, chromosomal deletion, or copy-neutral loss of heterozygosity. TP53 mutations are associated with enhanced chromosomal instability, including increased amplification of oncogenes and deep deletion of tumor suppressor genes. Tumors with TP53 mutations differ from their non-mutated counterparts in RNA, miRNA, and protein expression patterns, with mutant TP53 tumors displaying enhanced expression of cell cycle progression genes and proteins. A mutant TP53 RNA expression signature shows significant correlation with reduced survival in 11 cancer types. Thus, TP53 mutation has profound effects on tumor cell genomic structure, expression, and clinical outlook.
Identifiants
pubmed: 31365877
pii: S2211-1247(19)30885-X
doi: 10.1016/j.celrep.2019.07.001
pmc: PMC7546539
mid: NIHMS1633512
pii:
doi:
Substances chimiques
MicroRNAs
0
RNA, Neoplasm
0
TP53 protein, human
0
Tumor Suppressor Protein p53
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1370-1384.e5Subventions
Organisme : NCI NIH HHS
ID : U24 CA210950
Pays : United States
Organisme : NCI NIH HHS
ID : U24 CA210949
Pays : United States
Organisme : NCI NIH HHS
ID : U24 CA199461
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA100420
Pays : United States
Organisme : NHGRI NIH HHS
ID : UM1 HG008898
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA016672
Pays : United States
Commentaires et corrections
Type : ErratumIn
Informations de copyright
Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.
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