RIFM fragrance ingredient safety assessment, methyl ionone (mixture of isomers), CAS registry number 1335-46-2.

Animals Cell Line Consumer Product Safety Drug Evaluation, Preclinical Endpoint Determination Escherichia coli / drug effects Humans Isomerism Mutagenicity Tests No-Observed-Adverse-Effect Level Odorants Risk Assessment Salmonella typhimurium / drug effects Terpenes / chemistry

Journal

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
ISSN: 1873-6351
Titre abrégé: Food Chem Toxicol
Pays: England
ID NLM: 8207483

Informations de publication

Date de publication:
Dec 2019
Historique:
received: 05 06 2019
revised: 24 07 2019
accepted: 25 07 2019
pubmed: 1 8 2019
medline: 29 1 2020
entrez: 1 8 2019
Statut: ppublish

Résumé

Methyl ionone (mixture of isomers) was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from methyl ionone (mixture of isomers) show that the material is not genotoxic and provided a NESIL of 70,000 μg/cm

Identifiants

DOI: 10.1016/j.fct.2019.110716 PMID: 31365887
pubmed: 31365887
pii: S0278-6915(19)30506-X
doi: 10.1016/j.fct.2019.110716
pii:
doi:

Substances chimiques

Terpenes 0
methylionone 1335-46-2

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

110716

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

A M Api (AM)

Research Institute for Fragrance Materials, Inc, 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA.

D Belsito (D)

Member Expert Panel, Columbia University Medical Center, Department of Dermatology, 161 Fort Washington Ave., New York, NY, 10032, USA.

S Biserta (S)

Research Institute for Fragrance Materials, Inc, 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA.

D Botelho (D)

Research Institute for Fragrance Materials, Inc, 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA.

M Bruze (M)

Member Expert Panel, Malmo University Hospital, Department of Occupational & Environmental Dermatology, Sodra Forstadsgatan 101, Entrance 47, Malmo, SE-20502, Sweden.

G A Burton (GA)

Member Expert Panel, School of Natural Resources & Environment, University of Michigan, Dana Building G110, 440 Church St., Ann Arbor, MI, 58109, USA.

J Buschmann (J)

Member Expert Panel, Fraunhofer Institute for Toxicology and Experimental Medicine, Nikolai-Fuchs-Strasse 1, 30625, Hannover, Germany.

M A Cancellieri (MA)

Research Institute for Fragrance Materials, Inc, 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA.

M L Dagli (ML)

Member Expert Panel, University of Sao Paulo, School of Veterinary Medicine and Animal Science, Department of Pathology, Av. Prof. Dr. Orlando Marques de Paiva, 87, Sao Paulo CEP, 05508-900, Brazil.

M Date (M)

Research Institute for Fragrance Materials, Inc, 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA.

W Dekant (W)

Member Expert Panel, University of Wuerzburg, Department of Toxicology, Versbacher Str. 9, 97078, Würzburg, Germany.

C Deodhar (C)

Research Institute for Fragrance Materials, Inc, 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA.

A D Fryer (AD)

Member Expert Panel, Oregon Health Science University, 3181 SW Sam Jackson Park Rd., Portland, OR, 97239, USA.

S Gadhia (S)

Research Institute for Fragrance Materials, Inc, 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA.

L Jones (L)

Research Institute for Fragrance Materials, Inc, 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA.

K Joshi (K)

Research Institute for Fragrance Materials, Inc, 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA.

A Lapczynski (A)

Research Institute for Fragrance Materials, Inc, 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA.

M Lavelle (M)

Research Institute for Fragrance Materials, Inc, 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA.

D C Liebler (DC)

Member Expert Panel, Vanderbilt University School of Medicine, Department of Biochemistry, Center in Molecular Toxicology, 638 Robinson Research Building, 2200 Pierce Avenue, Nashville, TN, 37232-0146, USA.

M Na (M)

Research Institute for Fragrance Materials, Inc, 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA.

D O'Brien (D)

Research Institute for Fragrance Materials, Inc, 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA.

A Patel (A)

Research Institute for Fragrance Materials, Inc, 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA.

T M Penning (TM)

Member of Expert Panel, University of Pennsylvania, Perelman School of Medicine, Center of Excellence in Environmental Toxicology, 1316 Biomedical Research Building (BRB) II/III, 421 Curie Boulevard, Philadelphia, PA, 19104-3083, USA.

G Ritacco (G)

Research Institute for Fragrance Materials, Inc, 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA.

F Rodriguez-Ropero (F)

Research Institute for Fragrance Materials, Inc, 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA.

J Romine (J)

Research Institute for Fragrance Materials, Inc, 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA.

N Sadekar (N)

Research Institute for Fragrance Materials, Inc, 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA.

D Salvito (D)

Research Institute for Fragrance Materials, Inc, 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA.

T W Schultz (TW)

Member Expert Panel, The University of Tennessee, College of Veterinary Medicine, Department of Comparative Medicine, 2407 River Dr., Knoxville, TN, 37996- 4500, USA.

F Siddiqi (F)

Research Institute for Fragrance Materials, Inc, 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA.

I G Sipes (IG)

Member Expert Panel, Department of Pharmacology, University of Arizona, College of Medicine, 1501 North Campbell Avenue, P.O. Box 245050, Tucson, AZ, 85724-5050, USA.

G Sullivan (G)

Research Institute for Fragrance Materials, Inc, 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA. Electronic address: gsullivan@rifm.org.

Y Thakkar (Y)

Research Institute for Fragrance Materials, Inc, 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA.

Y Tokura (Y)

Member Expert Panel, The Journal of Dermatological Science (JDS), Editor-in-Chief, Professor and Chairman, Department of Dermatology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan.

S Tsang (S)

Research Institute for Fragrance Materials, Inc, 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › RIFM fragrance ingredient safety assessment,...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › RIFM fragrance ingredient safety assessment,...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Sécurité des produits de consommation › RIFM fragrance ingredient safety assessment,...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › RIFM fragrance ingredient safety assessment,...
questionsmedicales.fr › Techniques d'investigation › Détermination du point final › RIFM fragrance ingredient safety assessment,...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › RIFM fragrance ingredient safety assessment,...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › RIFM fragrance ingredient safety assessment,...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes de chimie organique › Isomérie › RIFM fragrance ingredient safety assessment,...
questionsmedicales.fr › Techniques d'investigation › Tests de toxicité › Tests de mutagénicité › RIFM fragrance ingredient safety assessment,...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Dose sans effet nocif observé › RIFM fragrance ingredient safety assessment,...
questionsmedicales.fr › Environnement et santé publique › Environnement › Odorisants › RIFM fragrance ingredient safety assessment,...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Appréciation des risques › RIFM fragrance ingredient safety assessment,...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Salmonella › Salmonella enterica › Salmonella typhimurium › RIFM fragrance ingredient safety assessment,...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › RIFM fragrance ingredient safety assessment,...