The Possible Causal Link of Periodontitis to Neuropsychiatric Disorders: More Than Psychosocial Mechanisms.
Alzheimer’s disease
Parkinson’s disease
major depression
microglia
neuroinflammation
neuropsychiatric disorders
periodontitis
schizophrenia
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
30 Jul 2019
30 Jul 2019
Historique:
received:
22
05
2019
revised:
19
07
2019
accepted:
25
07
2019
entrez:
2
8
2019
pubmed:
2
8
2019
medline:
24
12
2019
Statut:
epublish
Résumé
Increasing evidence implies a possible causal link between periodontitis and neuropsychiatric disorders, such as Alzheimer's disease (AD) and major depression (MD). A possible mechanism underlying such a link can be explained by neuroinflammation induced by chronic systemic inflammation. This review article focuses on an overview of the biological and epidemiological evidence for a feasible causal link of periodontitis to neuropsychiatric disorders, including AD, MD, Parkinson's disease, and schizophrenia, as well as the neurological event, ischemic stroke. If there is such a link, a broad spectrum of neuropsychiatric disorders associated with neuroinflammation could be preventable and modifiable by simple daily dealings for oral hygiene. However, the notion that periodontitis is a risk factor for neuropsychiatric disorders remains to be effectively substantiated.
Identifiants
pubmed: 31366073
pii: ijms20153723
doi: 10.3390/ijms20153723
pmc: PMC6695849
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Japan Society for the Promotion of Science
ID : 19K08018
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