Antitumor Effect of a Novel Photodynamic Therapy With Acetylated Glucose-conjugated Chlorin for Gastrointestinal Cancers.
Acetylation
/ drug effects
Animals
Apoptosis
/ drug effects
Cell Line, Tumor
Endoplasmic Reticulum
/ drug effects
Flow Cytometry
Gastrointestinal Neoplasms
/ pathology
Glucose
/ administration & dosage
Humans
Mice
Photochemotherapy
Photosensitizing Agents
/ administration & dosage
Porphyrins
/ administration & dosage
Xenograft Model Antitumor Assays
Acetylated glycose-conjugated chlorin
gastrointestinal cancer
photodynamic therapy
Journal
Anticancer research
ISSN: 1791-7530
Titre abrégé: Anticancer Res
Pays: Greece
ID NLM: 8102988
Informations de publication
Date de publication:
Aug 2019
Aug 2019
Historique:
received:
25
06
2019
revised:
03
07
2019
accepted:
04
07
2019
entrez:
2
8
2019
pubmed:
2
8
2019
medline:
8
8
2019
Statut:
ppublish
Résumé
We previously synthesized a glucose-conjugated chlorin compound e6 (G-chlorin e6), and reported that it has very strong antitumor effects. The aim of the present study was to synthesize acetylated glucose-conjugated chlorin (AcN003HP) and evaluate its antitumor effect and excretion. To evaluate the antitumor effect of AcN003HP, its IC AcN003HP showed stronger antitumor effects and accumulation into cancer cells compared to talaporfin sodium, a conventional photosensitizer. AcN003HP was localized in the endoplasmic reticulum. In a xenograft tumor mouse model, AcN003HP showed longer excretion time from the body than G-chlorin e6, and photodynamic therapy using AcN003HP showed very strong antitumor effects. The safety, improved controllability, and robust antitumor effects suggest AcN003HP as a good next-generation photosensitizer.
Sections du résumé
BACKGROUND/AIM
OBJECTIVE
We previously synthesized a glucose-conjugated chlorin compound e6 (G-chlorin e6), and reported that it has very strong antitumor effects. The aim of the present study was to synthesize acetylated glucose-conjugated chlorin (AcN003HP) and evaluate its antitumor effect and excretion.
MATERIALS AND METHODS
METHODS
To evaluate the antitumor effect of AcN003HP, its IC
RESULTS
RESULTS
AcN003HP showed stronger antitumor effects and accumulation into cancer cells compared to talaporfin sodium, a conventional photosensitizer. AcN003HP was localized in the endoplasmic reticulum. In a xenograft tumor mouse model, AcN003HP showed longer excretion time from the body than G-chlorin e6, and photodynamic therapy using AcN003HP showed very strong antitumor effects.
CONCLUSION
CONCLUSIONS
The safety, improved controllability, and robust antitumor effects suggest AcN003HP as a good next-generation photosensitizer.
Identifiants
pubmed: 31366506
pii: 39/8/4199
doi: 10.21873/anticanres.13580
doi:
Substances chimiques
Photosensitizing Agents
0
Porphyrins
0
chlorin
2683-84-3
Glucose
IY9XDZ35W2
Talaporfin
P4ROX5ELT2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4199-4206Informations de copyright
Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.