Preventive Effect of Oral Administration of
Hypertensive
Pantoea agglomerans-derived LPS
oral administration
salt loading
Journal
Anticancer research
ISSN: 1791-7530
Titre abrégé: Anticancer Res
Pays: Greece
ID NLM: 8102988
Informations de publication
Date de publication:
Aug 2019
Aug 2019
Historique:
received:
23
05
2019
revised:
26
06
2019
accepted:
02
07
2019
entrez:
2
8
2019
pubmed:
2
8
2019
medline:
7
8
2019
Statut:
ppublish
Résumé
Oral administration of Pantoea agglomerans-derived lipopolysaccharide (LPSp) has been reported to have a preventive effect against various lifestyle-related diseases. Therefore, we examined the preventive effect on high blood pressure, which is a kind of reserve arm for lifestyle-related diseases. Spontaneous hypertensive rat (SHR) and WKY rat were bred from 6 to 16 weeks of age. SHR were orally administered 100 μg/kg LPSp and 0.1% NaCl, and blood pressure was measured at 6, 10, 13 and 16 weeks. Furthermore, at 16 weeks of age, blood biochemical markers were measured and microbial community composition was analyzed. SHRs developed hypertension with age, which was exacerbated by salt loading. Although there was almost no reduction in blood pressure in SHRs that received LPSp. It was suppressed at 13-16 weeks of age in those with salt loading. Oral administration of LPSp showed a preventive effect on salt-loaded hypertension.
Sections du résumé
BACKGROUND/AIM
OBJECTIVE
Oral administration of Pantoea agglomerans-derived lipopolysaccharide (LPSp) has been reported to have a preventive effect against various lifestyle-related diseases. Therefore, we examined the preventive effect on high blood pressure, which is a kind of reserve arm for lifestyle-related diseases.
MATERIALS AND METHODS
METHODS
Spontaneous hypertensive rat (SHR) and WKY rat were bred from 6 to 16 weeks of age. SHR were orally administered 100 μg/kg LPSp and 0.1% NaCl, and blood pressure was measured at 6, 10, 13 and 16 weeks. Furthermore, at 16 weeks of age, blood biochemical markers were measured and microbial community composition was analyzed.
RESULTS
RESULTS
SHRs developed hypertension with age, which was exacerbated by salt loading. Although there was almost no reduction in blood pressure in SHRs that received LPSp. It was suppressed at 13-16 weeks of age in those with salt loading.
CONCLUSION
CONCLUSIONS
Oral administration of LPSp showed a preventive effect on salt-loaded hypertension.
Identifiants
pubmed: 31366552
pii: 39/8/4503
doi: 10.21873/anticanres.13626
doi:
Substances chimiques
Cytokines
0
Lipopolysaccharides
0
Salts
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4503-4509Informations de copyright
Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.