Design and Synthesis of Imidazole and Triazole Pyrazoles as

Binding affinity Imidazole derivatives X-ray crystallography molecular modelling mycobacterium tuberculosis

Journal

ChemistryOpen
ISSN: 2191-1363
Titre abrégé: ChemistryOpen
Pays: Germany
ID NLM: 101594811

Informations de publication

Date de publication:
Jul 2019
Historique:
received: 08 07 2019
entrez: 2 8 2019
pubmed: 2 8 2019
medline: 2 8 2019
Statut: epublish

Résumé

The emergence of untreatable drug-resistant strains of

Identifiants

pubmed: 31367508
doi: 10.1002/open.201900227
pii: OPEN201900227
pmc: PMC6646865
doi:

Types de publication

Journal Article

Langues

eng

Pagination

995-1011

Subventions

Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/M017702/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : FC001060
Pays : United Kingdom
Organisme : Wellcome Trust
ID : FC001060
Pays : United Kingdom

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

Références

Future Med Chem. 2010 Aug;2(8):1339-53
pubmed: 21426022
Proc Natl Acad Sci U S A. 2009 May 5;106(18):7426-31
pubmed: 19416919
J Chem Inf Comput Sci. 1987 Feb;27(1):21-35
pubmed: 3558506
ChemMedChem. 2017 Oct 9;12(19):1616-1626
pubmed: 28815923
Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):125-32
pubmed: 20124692
Bioorg Med Chem Lett. 2013 Feb 1;23(3):624-6
pubmed: 23290053
BMJ. 2015 Feb 26;350:h882
pubmed: 25721508
Bioorg Med Chem. 2018 Jan 1;26(1):161-176
pubmed: 29183661
Infect Dis Clin North Am. 2016 Jun;30(2):509-522
pubmed: 27208770
ChemistryOpen. 2019 Jul 23;8(7):995-1011
pubmed: 31367508
Arch Biochem Biophys. 2007 Aug 15;464(2):228-40
pubmed: 17482138
Antimicrob Agents Chemother. 2002 Aug;46(8):2720-2
pubmed: 12121966
Acta Crystallogr D Biol Crystallogr. 2010 Jan;66(Pt 1):12-21
pubmed: 20057044
Bioorg Med Chem Lett. 2012 Apr 15;22(8):2708-11
pubmed: 22437116
Nat Rev Drug Discov. 2013 May;12(5):388-404
pubmed: 23629506
IUCrJ. 2014 May 30;1(Pt 4):213-20
pubmed: 25075342
J Bacteriol. 2006 Mar;188(6):2214-21
pubmed: 16513751
Acta Crystallogr D Biol Crystallogr. 2010 Apr;66(Pt 4):486-501
pubmed: 20383002
J Med Chem. 2017 Dec 28;60(24):10257-10267
pubmed: 29185746
Microbiology (Reading). 2002 Oct;148(Pt 10):2937-2949
pubmed: 12368427
ChemMedChem. 2016 Sep 6;11(17):1924-35
pubmed: 27432475
Angew Chem Int Ed Engl. 2012 Sep 10;51(37):9311-6
pubmed: 22890978
Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):213-21
pubmed: 20124702

Auteurs

Safaa M Kishk (SM)

School of Pharmacy & Pharmaceutical Sciences Cardiff University King Edward VII Avenue Cardiff CF10 3NB U.K.
Medicinal Chemistry Department, Faculty of Pharmacy Suez Canal University Ismailia Egypt.

Kirsty J McLean (KJ)

Manchester Institute of Biotechnology, School of Chemistry University of Manchester 131 Princess Street Manchester M1 7DN U.K.

Sakshi Sood (S)

Mycobacterial Metabolism and Antibiotic Research Laboratory The Francis Crick Institute 1 Midland Road London NW1 1AT U.K.

Darren Smith (D)

School of Pharmacy & Pharmaceutical Sciences Cardiff University King Edward VII Avenue Cardiff CF10 3NB U.K.

Jack W D Evans (JWD)

School of Pharmacy & Pharmaceutical Sciences Cardiff University King Edward VII Avenue Cardiff CF10 3NB U.K.

Mohamed A Helal (MA)

Medicinal Chemistry Department, Faculty of Pharmacy Suez Canal University Ismailia Egypt.
Biomedical Sciences Program University of Science and Technology Zewail City of Science and Technology Giza 12588 Egypt.

Mohamed S Gomaa (MS)

Medicinal Chemistry Department, Faculty of Pharmacy Suez Canal University Ismailia Egypt.
Department of Chemistry College of Clinical Pharmacy Imam Abdulrahman Bin Faisal University Dammam Kingdom of Saudi Arabia.

Ismail Salama (I)

Medicinal Chemistry Department, Faculty of Pharmacy Suez Canal University Ismailia Egypt.

Samia M Mostafa (SM)

Medicinal Chemistry Department, Faculty of Pharmacy Suez Canal University Ismailia Egypt.

Luiz Pedro S de Carvalho (LPS)

Mycobacterial Metabolism and Antibiotic Research Laboratory The Francis Crick Institute 1 Midland Road London NW1 1AT U.K.

Colin W Levy (CW)

Manchester Institute of Biotechnology, School of Chemistry University of Manchester 131 Princess Street Manchester M1 7DN U.K.

Andrew W Munro (AW)

Manchester Institute of Biotechnology, School of Chemistry University of Manchester 131 Princess Street Manchester M1 7DN U.K.

Claire Simons (C)

School of Pharmacy & Pharmaceutical Sciences Cardiff University King Edward VII Avenue Cardiff CF10 3NB U.K.

Classifications MeSH