Monte Carlo Simulation of the Treatment of Uveal Melanoma Using Measured Heterogeneous
Beta emitter
Brachytherapy
Eye plaques
Monte Carlo simulation
PENELOPE
Ruthenium
Treatment planning
Uveal melanoma
Journal
Ocular oncology and pathology
ISSN: 2296-4681
Titre abrégé: Ocul Oncol Pathol
Pays: Switzerland
ID NLM: 101656139
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
received:
11
04
2018
revised:
31
07
2018
entrez:
2
8
2019
pubmed:
2
8
2019
medline:
2
8
2019
Statut:
ppublish
Résumé
Ruthenium plaques are used for the treatment of ocular tumors. The aim of this work is the comparison between simulated absorbed dose distributions tallied in an anthropomorphic phantom, obtained from ideal homogeneous plaques, and real eye plaques in which the actual heterogeneous distribution of The generic CCA and CCB, and the specific CCA1364 and CCB1256 Eccentric placements of the plaques, taking into account the inhomogeneities of the emitter map, can substantially reduce the dose delivered to structures at risk while maintaining the prescribed dose at the tumor apex. The emitter map distribution of the plaque and the computerized tomography of the patient used in a Monte Carlo simulation allow an accurate determination of the plaque position with respect to the tumor with the potential to reduce the dose to sensitive structures.
Sections du résumé
BACKGROUND/AIMS
OBJECTIVE
Ruthenium plaques are used for the treatment of ocular tumors. The aim of this work is the comparison between simulated absorbed dose distributions tallied in an anthropomorphic phantom, obtained from ideal homogeneous plaques, and real eye plaques in which the actual heterogeneous distribution of
METHODS
METHODS
The generic CCA and CCB, and the specific CCA1364 and CCB1256
RESULTS
RESULTS
Eccentric placements of the plaques, taking into account the inhomogeneities of the emitter map, can substantially reduce the dose delivered to structures at risk while maintaining the prescribed dose at the tumor apex.
CONCLUSIONS
CONCLUSIONS
The emitter map distribution of the plaque and the computerized tomography of the patient used in a Monte Carlo simulation allow an accurate determination of the plaque position with respect to the tumor with the potential to reduce the dose to sensitive structures.
Identifiants
pubmed: 31367591
doi: 10.1159/000492599
pii: oop-0005-0276
pmc: PMC6615327
doi:
Types de publication
Journal Article
Langues
eng
Pagination
276-283Déclaration de conflit d'intérêts
The authors are thankful to the Deutsche Forschungsgemeinschaft (projects BR 4043/3-1, FL 733/1-1, and EI 869/1-3). The authors declare that there does not exist any conflict of interest.
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