Cholestatic liver diseases: An era of emerging therapies.
Bile acids
Cholestatic liver disease
Drug therapy
Nuclear receptor agonists
Journal
World journal of clinical cases
ISSN: 2307-8960
Titre abrégé: World J Clin Cases
Pays: United States
ID NLM: 101618806
Informations de publication
Date de publication:
06 Jul 2019
06 Jul 2019
Historique:
received:
10
01
2019
revised:
05
06
2019
accepted:
10
06
2019
entrez:
2
8
2019
pubmed:
2
8
2019
medline:
2
8
2019
Statut:
ppublish
Résumé
Recently the field of cholestasis has expanded enormously reflecting an improved understanding of the molecular mechanisms underlying bile secretion and its perturbation in chronic cholestatic disease. Novel anti-cholestatic therapeutic options have been developed for patients not favorably responding to ursodeoxycholic acid (UDCA), the current standard treatment for cholestatic liver disease. Important novel treatment targets now also include nuclear receptors involved in bile acid (BA) homoeostasis like farnesoid X receptor and G protein-coupled receptors
Identifiants
pubmed: 31367616
doi: 10.12998/wjcc.v7.i13.1571
pmc: PMC6658370
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1571-1581Déclaration de conflit d'intérêts
Conflict-of-interest statement: The authors declare that there is no conflict of interest regarding the publication of this paper.
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