Extracellular Vesicles in Type 1 Diabetes: Messengers and Regulators.
Antigen Presentation
/ immunology
Autoantigens
/ immunology
Autoimmunity
/ immunology
Biomarkers
/ analysis
Cell Communication
/ immunology
Diabetes Mellitus, Type 1
/ diagnosis
Extracellular Vesicles
/ immunology
Humans
Insulin-Secreting Cells
/ immunology
Islets of Langerhans
/ immunology
MicroRNAs
/ immunology
Autoimmunity
Biomarkers
Extracellular vesicles
Islets of Langerhans
Type 1 diabetes
β-cell injury
Journal
Current diabetes reports
ISSN: 1539-0829
Titre abrégé: Curr Diab Rep
Pays: United States
ID NLM: 101093791
Informations de publication
Date de publication:
31 07 2019
31 07 2019
Historique:
entrez:
2
8
2019
pubmed:
2
8
2019
medline:
26
3
2020
Statut:
epublish
Résumé
Theories about the pathogenesis of type 1 diabetes (T1D) refer to the potential of primary islet inflammatory signaling as a trigger for the loss of self-tolerance leading to disease onset. Emerging evidence suggests that extracellular vesicles (EV) may represent the missing link between inflammation and autoimmunity. Here, we review the evidence for a role of EV in the pathogenesis of T1D, as well as discuss their potential value in the clinical sphere, as biomarkers and therapeutic agents. EV derived from β cells are enriched in diabetogenic autoantigens and miRNAs that are selectively sorted and packaged. These EV play a pivotal role in antigen presentation and cell to cell communication leading to activation of autoimmune responses. Furthermore, recent evidence suggests the potential of EV as novel tools in clinical diagnostics and therapeutic interventions. In-depth analysis of EV cargo using modern multi-parametric technologies may be useful in enhancing our understanding of EV-mediated immune mechanisms and in identifying robust biomarkers and therapeutic strategies for T1D.
Identifiants
pubmed: 31367976
doi: 10.1007/s11892-019-1193-7
pii: 10.1007/s11892-019-1193-7
doi:
Substances chimiques
Autoantigens
0
Biomarkers
0
MicroRNAs
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
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