Boron containing compounds promote the survival and the maintenance of pancreatic β-cells.
Boric acid
Diabetes mellitus
Pancreatic β cells
Sodium pentaborate pentahydrate
Type 1 diabetes
Journal
Molecular biology reports
ISSN: 1573-4978
Titre abrégé: Mol Biol Rep
Pays: Netherlands
ID NLM: 0403234
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
06
02
2019
accepted:
24
07
2019
pubmed:
2
8
2019
medline:
10
3
2020
entrez:
2
8
2019
Statut:
ppublish
Résumé
Diabetes mellitus is worldwide disease. The life of diabetic patients are dependent on exogenous insulin. Pancreas or particularly islet transplantations are performed for reducing external insulin dependency. External substances are also used to protect the β-cells from the death or increase insulin secretion. In the current study, two different boron containing compounds (sodium pentaborate pentahydrate-NaB and boric acid-BA) were investigated for their effect on pancreatic cells in terms of pro-apoptotic and anti-apoptotic markers, genes related to insulin production mechanism, pancreatic development and glucose metabolism, some antioxidant enzymes, and genes for the initiation of diabetes, insulin secretion and antioxidant enzyme activities in vitro. The results revealed that boron containing compounds did not lead to apoptosis. On the contrary, they increased cell viability, antioxidant enzyme activities and the level of genes related to insulin production. Overall evaluation, data in the current study showed that boron containing compounds might be promising therapeutic agents for type 1 diabetes. However, additional investigations are strictly needed to elucidate molecular mechanisms of boron containing compounds.
Identifiants
pubmed: 31368021
doi: 10.1007/s11033-019-05002-3
pii: 10.1007/s11033-019-05002-3
doi:
Substances chimiques
Annexin A5
0
Borates
0
Boric Acids
0
Insulin
0
Glutathione Peroxidase
EC 1.11.1.9
Superoxide Dismutase
EC 1.15.1.1
Boron
N9E3X5056Q
boric acid
R57ZHV85D4
sodium pentaborate
XQG9Q75WDN
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5465-5478Références
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